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Evaluation of the alpha(2A)-adrenergic receptor gene in a heritable form of temporal lobe epilepsy.

Publication ,  Journal Article
Wilson, MH; Puranam, RS; Ottman, R; Gilliam, C; Limbird, LE; George, AL; McNamara, JO
Published in: Neurology
December 1998

An autosomal dominant form of human temporal lobe epilepsy (TLE) has been mapped to a region of chromosome 10q that contains the intronless alpha(2A)-adrenergic receptor (alpha(2A)AR) gene. Because mutation of the alpha(2A)AR gene in the mouse fosters epileptogenesis, we developed methods for analysis of the alpha(2A)AR coding region applicable to any pathophysiologic state in which the alpha(2A)AR could be implicated in the disease mechanism. This study rules out mutations in the alpha(2A)AR coding region as causal for this form of autosomal dominant TLE.

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Published In

Neurology

DOI

ISSN

0028-3878

Publication Date

December 1998

Volume

51

Issue

6

Start / End Page

1730 / 1731

Location

United States

Related Subject Headings

  • Receptors, Adrenergic, alpha-2
  • Neurology & Neurosurgery
  • Mutation
  • Mice
  • Humans
  • Genes, Dominant
  • Epilepsy, Temporal Lobe
  • DNA Primers
  • Chromosomes, Human, Pair 10
  • Brain Chemistry
 

Citation

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Wilson, M. H., Puranam, R. S., Ottman, R., Gilliam, C., Limbird, L. E., George, A. L., & McNamara, J. O. (1998). Evaluation of the alpha(2A)-adrenergic receptor gene in a heritable form of temporal lobe epilepsy. Neurology, 51(6), 1730–1731. https://doi.org/10.1212/wnl.51.6.1730
Wilson, M. H., R. S. Puranam, R. Ottman, C. Gilliam, L. E. Limbird, A. L. George, and J. O. McNamara. “Evaluation of the alpha(2A)-adrenergic receptor gene in a heritable form of temporal lobe epilepsy.Neurology 51, no. 6 (December 1998): 1730–31. https://doi.org/10.1212/wnl.51.6.1730.
Wilson MH, Puranam RS, Ottman R, Gilliam C, Limbird LE, George AL, et al. Evaluation of the alpha(2A)-adrenergic receptor gene in a heritable form of temporal lobe epilepsy. Neurology. 1998 Dec;51(6):1730–1.
Wilson, M. H., et al. “Evaluation of the alpha(2A)-adrenergic receptor gene in a heritable form of temporal lobe epilepsy.Neurology, vol. 51, no. 6, Dec. 1998, pp. 1730–31. Pubmed, doi:10.1212/wnl.51.6.1730.
Wilson MH, Puranam RS, Ottman R, Gilliam C, Limbird LE, George AL, McNamara JO. Evaluation of the alpha(2A)-adrenergic receptor gene in a heritable form of temporal lobe epilepsy. Neurology. 1998 Dec;51(6):1730–1731.

Published In

Neurology

DOI

ISSN

0028-3878

Publication Date

December 1998

Volume

51

Issue

6

Start / End Page

1730 / 1731

Location

United States

Related Subject Headings

  • Receptors, Adrenergic, alpha-2
  • Neurology & Neurosurgery
  • Mutation
  • Mice
  • Humans
  • Genes, Dominant
  • Epilepsy, Temporal Lobe
  • DNA Primers
  • Chromosomes, Human, Pair 10
  • Brain Chemistry