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Anti-seizure and anti-epileptogenic effect of gamma-vinyl gamma-aminobutyric acid in amygdaloid kindling.

Publication ,  Journal Article
Shin, C; Rigsbee, LC; McNamara, JO
Published in: Brain Res
November 29, 1986

We examined the effects of systemic administration of gamma-vinyl gamma-aminobutyric acid (GVG), a gamma-aminobutyric acid (GABA) transaminase inhibitor, on the kindling model of epilepsy in rats. GVG (1200 or 1500 mg/kg) approximately doubled the number of stimulations required for kindling development. GVG also suppressed both generalized motor seizures and electrographic after discharges in previously fully kindled animals. These results further support the idea that enhanced GABAergic neurotransmission suppresses both seizures and epileptogenesis. The results also suggest that GVG may be an effective anti-seizure and anti-epileptogenic agent in humans.

Duke Scholars

Published In

Brain Res

DOI

ISSN

0006-8993

Publication Date

November 29, 1986

Volume

398

Issue

2

Start / End Page

370 / 374

Location

Netherlands

Related Subject Headings

  • gamma-Aminobutyric Acid
  • Vigabatrin
  • Synaptic Transmission
  • Rats, Inbred Strains
  • Rats
  • Neurology & Neurosurgery
  • Male
  • Kindling, Neurologic
  • Epilepsy, Temporal Lobe
  • Electrophysiology
 

Citation

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ICMJE
MLA
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Shin, C., Rigsbee, L. C., & McNamara, J. O. (1986). Anti-seizure and anti-epileptogenic effect of gamma-vinyl gamma-aminobutyric acid in amygdaloid kindling. Brain Res, 398(2), 370–374. https://doi.org/10.1016/0006-8993(86)91498-8
Shin, C., L. C. Rigsbee, and J. O. McNamara. “Anti-seizure and anti-epileptogenic effect of gamma-vinyl gamma-aminobutyric acid in amygdaloid kindling.Brain Res 398, no. 2 (November 29, 1986): 370–74. https://doi.org/10.1016/0006-8993(86)91498-8.
Shin C, Rigsbee LC, McNamara JO. Anti-seizure and anti-epileptogenic effect of gamma-vinyl gamma-aminobutyric acid in amygdaloid kindling. Brain Res. 1986 Nov 29;398(2):370–4.
Shin, C., et al. “Anti-seizure and anti-epileptogenic effect of gamma-vinyl gamma-aminobutyric acid in amygdaloid kindling.Brain Res, vol. 398, no. 2, Nov. 1986, pp. 370–74. Pubmed, doi:10.1016/0006-8993(86)91498-8.
Shin C, Rigsbee LC, McNamara JO. Anti-seizure and anti-epileptogenic effect of gamma-vinyl gamma-aminobutyric acid in amygdaloid kindling. Brain Res. 1986 Nov 29;398(2):370–374.
Journal cover image

Published In

Brain Res

DOI

ISSN

0006-8993

Publication Date

November 29, 1986

Volume

398

Issue

2

Start / End Page

370 / 374

Location

Netherlands

Related Subject Headings

  • gamma-Aminobutyric Acid
  • Vigabatrin
  • Synaptic Transmission
  • Rats, Inbred Strains
  • Rats
  • Neurology & Neurosurgery
  • Male
  • Kindling, Neurologic
  • Epilepsy, Temporal Lobe
  • Electrophysiology