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Predictors of severe gastrointestinal toxicity after external beam radiotherapy and interstitial brachytherapy for advanced or recurrent gynecologic malignancies.

Publication ,  Journal Article
Kasibhatla, M; Clough, RW; Montana, GS; Oleson, JR; Light, K; Steffey, BA; Jones, EL
Published in: Int J Radiat Oncol Biol Phys
June 1, 2006

PURPOSE: The aim of this retrospective review of patients with gynecologic malignancies treated with external beam radiotherapy (EBRT) and interstitial brachytherapy was to determine the rate of Grade > or =2 rectovaginal fistula and Grade > or =4 small bowel obstruction as defined by the National Cancer Institute Common Toxicity Criteria for Adverse Events, version 3.0. METHODS AND MATERIALS: Thirty-six patients with primary and recurrent gynecologic cancers were treated with EBRT and interstitial brachytherapy. Median doses to tumor, bladder, and rectum were 75 Gy, 61 Gy, and 61 Gy, respectively. A univariate analysis was performed to identify variables that correlated with toxicity. RESULTS: At median follow-up of 19 months, the 3-year risk of small bowel obstruction was 6%. Those patients with prior abdomino-pelvic surgery who received EBRT with antero-posterior fields had higher rates of obstruction than patients without prior abdomino-pelvic surgery or those who received EBRT with four fields (50% vs. 0%, p < 0.0001). The 3-year risk of rectovaginal fistula was 18% and was significantly higher in patients who received >76 Gy to the rectum compared with those who received < or =76 Gy (100% vs. 7%, p = 0.009). CONCLUSIONS: Patients treated with EBRT and interstitial brachytherapy after abdomino-pelvic surgery should receive EBRT with four fields and the cumulative rectal dose should be < or =76 Gy.

Duke Scholars

Published In

Int J Radiat Oncol Biol Phys

DOI

ISSN

0360-3016

Publication Date

June 1, 2006

Volume

65

Issue

2

Start / End Page

398 / 403

Location

United States

Related Subject Headings

  • Vaginal Neoplasms
  • Uterine Cervical Neoplasms
  • Retrospective Studies
  • Rectum
  • Rectovaginal Fistula
  • Radiation Injuries
  • Oncology & Carcinogenesis
  • Neoplasm Recurrence, Local
  • Middle Aged
  • Humans
 

Citation

APA
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ICMJE
MLA
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Kasibhatla, M., Clough, R. W., Montana, G. S., Oleson, J. R., Light, K., Steffey, B. A., & Jones, E. L. (2006). Predictors of severe gastrointestinal toxicity after external beam radiotherapy and interstitial brachytherapy for advanced or recurrent gynecologic malignancies. Int J Radiat Oncol Biol Phys, 65(2), 398–403. https://doi.org/10.1016/j.ijrobp.2005.12.008
Kasibhatla, Mohit, Robert W. Clough, Gustavo S. Montana, James R. Oleson, Kim Light, Beverley A. Steffey, and Ellen L. Jones. “Predictors of severe gastrointestinal toxicity after external beam radiotherapy and interstitial brachytherapy for advanced or recurrent gynecologic malignancies.Int J Radiat Oncol Biol Phys 65, no. 2 (June 1, 2006): 398–403. https://doi.org/10.1016/j.ijrobp.2005.12.008.
Kasibhatla M, Clough RW, Montana GS, Oleson JR, Light K, Steffey BA, et al. Predictors of severe gastrointestinal toxicity after external beam radiotherapy and interstitial brachytherapy for advanced or recurrent gynecologic malignancies. Int J Radiat Oncol Biol Phys. 2006 Jun 1;65(2):398–403.
Kasibhatla, Mohit, et al. “Predictors of severe gastrointestinal toxicity after external beam radiotherapy and interstitial brachytherapy for advanced or recurrent gynecologic malignancies.Int J Radiat Oncol Biol Phys, vol. 65, no. 2, June 2006, pp. 398–403. Pubmed, doi:10.1016/j.ijrobp.2005.12.008.
Kasibhatla M, Clough RW, Montana GS, Oleson JR, Light K, Steffey BA, Jones EL. Predictors of severe gastrointestinal toxicity after external beam radiotherapy and interstitial brachytherapy for advanced or recurrent gynecologic malignancies. Int J Radiat Oncol Biol Phys. 2006 Jun 1;65(2):398–403.
Journal cover image

Published In

Int J Radiat Oncol Biol Phys

DOI

ISSN

0360-3016

Publication Date

June 1, 2006

Volume

65

Issue

2

Start / End Page

398 / 403

Location

United States

Related Subject Headings

  • Vaginal Neoplasms
  • Uterine Cervical Neoplasms
  • Retrospective Studies
  • Rectum
  • Rectovaginal Fistula
  • Radiation Injuries
  • Oncology & Carcinogenesis
  • Neoplasm Recurrence, Local
  • Middle Aged
  • Humans