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Attenuated poxvirus-based simian immunodeficiency virus (SIV) vaccines given in infancy partially protect infant and juvenile macaques against repeated oral challenge with virulent SIV.

Publication ,  Journal Article
Van Rompay, KKA; Abel, K; Lawson, JR; Singh, RP; Schmidt, KA; Evans, T; Earl, P; Harvey, D; Franchini, G; Tartaglia, J; Montefiori, D; Moss, B ...
Published in: J Acquir Immune Defic Syndr
February 1, 2005

An infant macaque model was developed to test pediatric vaccine candidates aimed at reducing HIV transmission through breast-feeding. Infant macaques were given multiple immunizations during the first 3 weeks of life with recombinant poxvirus vaccines expressing simian immunodeficiency virus (SIV) structural proteins Gag, Pol, and Env (ALVAC-SIV or modified vaccinia virus Ankara [MVA]-SIV). After repeated daily oral inoculations with virulent SIVmac251 at 4 weeks of age, significantly fewer ALVAC-SIV-immunized infants were infected compared with unimmunized infants. Monkeys not infected after oral challenge in infancy were rechallenged at 16 months of age or older by repeated weekly oral SIV exposure; unimmunized animals were infected after fewer SIV exposures than were animals vaccinated with ALVAC-SIV or MVA-SIV. When infected, ALVAC-SIV- and MVA-SIV-vaccinated animals also had reduced viremia compared with unimmunized animals. The results of these investigations suggest that immunization of human infants with poxvirus-based HIV vaccine candidates may offer protection against early and late HIV infection through breastfeeding.

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Published In

J Acquir Immune Defic Syndr

DOI

ISSN

1525-4135

Publication Date

February 1, 2005

Volume

38

Issue

2

Start / End Page

124 / 134

Location

United States

Related Subject Headings

  • Virology
  • Viral Fusion Proteins
  • Vaccines, Synthetic
  • Vaccines, Attenuated
  • Simian immunodeficiency virus
  • Simian Immunodeficiency Virus
  • Simian Acquired Immunodeficiency Syndrome
  • SAIDS Vaccines
  • Retroviridae Proteins, Oncogenic
  • Poxviridae
 

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Van Rompay, K. K. A., Abel, K., Lawson, J. R., Singh, R. P., Schmidt, K. A., Evans, T., … Marthas, M. L. (2005). Attenuated poxvirus-based simian immunodeficiency virus (SIV) vaccines given in infancy partially protect infant and juvenile macaques against repeated oral challenge with virulent SIV. J Acquir Immune Defic Syndr, 38(2), 124–134. https://doi.org/10.1097/00126334-200502010-00002
Van Rompay, Koen K. A., Kristina Abel, Jonathan R. Lawson, Raman P. Singh, Kimberli A. Schmidt, Thomas Evans, Patricia Earl, et al. “Attenuated poxvirus-based simian immunodeficiency virus (SIV) vaccines given in infancy partially protect infant and juvenile macaques against repeated oral challenge with virulent SIV.J Acquir Immune Defic Syndr 38, no. 2 (February 1, 2005): 124–34. https://doi.org/10.1097/00126334-200502010-00002.
Van Rompay KKA, Abel K, Lawson JR, Singh RP, Schmidt KA, Evans T, et al. Attenuated poxvirus-based simian immunodeficiency virus (SIV) vaccines given in infancy partially protect infant and juvenile macaques against repeated oral challenge with virulent SIV. J Acquir Immune Defic Syndr. 2005 Feb 1;38(2):124–34.
Van Rompay, Koen K. A., et al. “Attenuated poxvirus-based simian immunodeficiency virus (SIV) vaccines given in infancy partially protect infant and juvenile macaques against repeated oral challenge with virulent SIV.J Acquir Immune Defic Syndr, vol. 38, no. 2, Feb. 2005, pp. 124–34. Pubmed, doi:10.1097/00126334-200502010-00002.
Van Rompay KKA, Abel K, Lawson JR, Singh RP, Schmidt KA, Evans T, Earl P, Harvey D, Franchini G, Tartaglia J, Montefiori D, Hattangadi S, Moss B, Marthas ML. Attenuated poxvirus-based simian immunodeficiency virus (SIV) vaccines given in infancy partially protect infant and juvenile macaques against repeated oral challenge with virulent SIV. J Acquir Immune Defic Syndr. 2005 Feb 1;38(2):124–134.

Published In

J Acquir Immune Defic Syndr

DOI

ISSN

1525-4135

Publication Date

February 1, 2005

Volume

38

Issue

2

Start / End Page

124 / 134

Location

United States

Related Subject Headings

  • Virology
  • Viral Fusion Proteins
  • Vaccines, Synthetic
  • Vaccines, Attenuated
  • Simian immunodeficiency virus
  • Simian Immunodeficiency Virus
  • Simian Acquired Immunodeficiency Syndrome
  • SAIDS Vaccines
  • Retroviridae Proteins, Oncogenic
  • Poxviridae