Skip to main content

Prevention of disease induced by a partially heterologous AIDS virus in rhesus monkeys by using an adjuvanted multicomponent protein vaccine.

Publication ,  Journal Article
Voss, G; Manson, K; Montefiori, D; Watkins, DI; Heeney, J; Wyand, M; Cohen, J; Bruck, C
Published in: J Virol
January 2003

Recombinant protein subunit AIDS vaccines have been based predominantly on the virus envelope protein. Such vaccines elicit neutralizing antibody responses that can provide type-specific sterilizing immunity, but in most cases do not confer protection against divergent viruses. In this report we demonstrate that a multiantigen subunit protein vaccine was able to prevent the development of disease induced in rhesus monkeys by a partially heterologous AIDS virus. The vaccine was composed of recombinant human immunodeficiency virus type 1 (HIV-1) gp120, NefTat fusion protein, and simian immunodeficiency virus (SIV) Nef formulated in the clinically tested adjuvant AS02A. Upon challenge of genetically unselected rhesus monkeys with the highly pathogenic and partially heterologous SIV/HIV strain SHIV(89.6p) the vaccine was able to reduce virus load and protect the animals from a decline in CD4-positive cells. Furthermore, vaccination prevented the development of AIDS for more than 2.5 years. The combination of the regulatory proteins Nef and Tat together with the structural protein gp120 was required for vaccine efficacy.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

J Virol

DOI

ISSN

0022-538X

Publication Date

January 2003

Volume

77

Issue

2

Start / End Page

1049 / 1058

Location

United States

Related Subject Headings

  • Virology
  • Viral Load
  • Simian immunodeficiency virus
  • Simian Immunodeficiency Virus
  • Neutralization Tests
  • Macaca mulatta
  • HIV-1
  • HIV Infections
  • HIV Antibodies
  • Chimera
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Voss, G., Manson, K., Montefiori, D., Watkins, D. I., Heeney, J., Wyand, M., … Bruck, C. (2003). Prevention of disease induced by a partially heterologous AIDS virus in rhesus monkeys by using an adjuvanted multicomponent protein vaccine. J Virol, 77(2), 1049–1058. https://doi.org/10.1128/jvi.77.2.1049-1058.2003
Voss, Gerald, Kelledy Manson, David Montefiori, David I. Watkins, Jonathan Heeney, Michael Wyand, Joe Cohen, and Claudine Bruck. “Prevention of disease induced by a partially heterologous AIDS virus in rhesus monkeys by using an adjuvanted multicomponent protein vaccine.J Virol 77, no. 2 (January 2003): 1049–58. https://doi.org/10.1128/jvi.77.2.1049-1058.2003.
Voss G, Manson K, Montefiori D, Watkins DI, Heeney J, Wyand M, et al. Prevention of disease induced by a partially heterologous AIDS virus in rhesus monkeys by using an adjuvanted multicomponent protein vaccine. J Virol. 2003 Jan;77(2):1049–58.
Voss, Gerald, et al. “Prevention of disease induced by a partially heterologous AIDS virus in rhesus monkeys by using an adjuvanted multicomponent protein vaccine.J Virol, vol. 77, no. 2, Jan. 2003, pp. 1049–58. Pubmed, doi:10.1128/jvi.77.2.1049-1058.2003.
Voss G, Manson K, Montefiori D, Watkins DI, Heeney J, Wyand M, Cohen J, Bruck C. Prevention of disease induced by a partially heterologous AIDS virus in rhesus monkeys by using an adjuvanted multicomponent protein vaccine. J Virol. 2003 Jan;77(2):1049–1058.

Published In

J Virol

DOI

ISSN

0022-538X

Publication Date

January 2003

Volume

77

Issue

2

Start / End Page

1049 / 1058

Location

United States

Related Subject Headings

  • Virology
  • Viral Load
  • Simian immunodeficiency virus
  • Simian Immunodeficiency Virus
  • Neutralization Tests
  • Macaca mulatta
  • HIV-1
  • HIV Infections
  • HIV Antibodies
  • Chimera