Skip to main content

A molecularly cloned, pathogenic, neutralization-resistant simian immunodeficiency virus, SIVsmE543-3.

Publication ,  Journal Article
Hirsch, V; Adger-Johnson, D; Campbell, B; Goldstein, S; Brown, C; Elkins, WR; Montefiori, DC
Published in: J Virol
February 1997

An infectious molecular clone of simian immunodeficiency virus SIVsm was derived from a biological isolate obtained late in disease from an immunodeficient rhesus macaque (E543) with SIV-induced encephalitis. The molecularly cloned virus, SIVsmE543-3, replicated well in macaque peripheral blood mononuclear cells and monocyte-derived macrophages and resisted neutralization by heterologous sera which broadly neutralized genetically diverse SIV variants in vitro. SIVsmE543-3 was infectious and induced AIDS when inoculated intravenously into pig-tailed macaques (Macaca nemestrina). Two of four infected macaques developed no measurable SIV-specific antibody and succumbed to a wasting syndrome and SIV-induced meningoencephalitis by 14 and 33 weeks postinfection. The other two macaques developed antibodies reactive in Western blot and virus neutralization assays. One macaque was sacrificed at 1 year postinoculation, and the survivor has evidence of immunodeficiency, characterized by persistently low CD4 lymphocyte subsets in the peripheral blood. Plasma samples from these latter animals neutralized SIVsmE543-3 but with much lower efficiency than neutralization of other related SIV strains, confirming the difficulty by which this molecularly cloned virus is neutralized in vitro. SIVsmE543-3 will provide a valuable reagent for studying SIV-induced encephalitis, mapping determinants of neutralization, and determining the in vivo significance of resistance to neutralization in vitro.

Duke Scholars

Published In

J Virol

DOI

ISSN

0022-538X

Publication Date

February 1997

Volume

71

Issue

2

Start / End Page

1608 / 1620

Location

United States

Related Subject Headings

  • Virulence
  • Virology
  • Simian immunodeficiency virus
  • Simian Immunodeficiency Virus
  • Simian Acquired Immunodeficiency Syndrome
  • Molecular Sequence Data
  • Macaca nemestrina
  • Genes, env
  • Antibodies, Viral
  • Animals
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Hirsch, V., Adger-Johnson, D., Campbell, B., Goldstein, S., Brown, C., Elkins, W. R., & Montefiori, D. C. (1997). A molecularly cloned, pathogenic, neutralization-resistant simian immunodeficiency virus, SIVsmE543-3. J Virol, 71(2), 1608–1620. https://doi.org/10.1128/JVI.71.2.1608-1620.1997
Hirsch, V., D. Adger-Johnson, B. Campbell, S. Goldstein, C. Brown, W. R. Elkins, and D. C. Montefiori. “A molecularly cloned, pathogenic, neutralization-resistant simian immunodeficiency virus, SIVsmE543-3.J Virol 71, no. 2 (February 1997): 1608–20. https://doi.org/10.1128/JVI.71.2.1608-1620.1997.
Hirsch V, Adger-Johnson D, Campbell B, Goldstein S, Brown C, Elkins WR, et al. A molecularly cloned, pathogenic, neutralization-resistant simian immunodeficiency virus, SIVsmE543-3. J Virol. 1997 Feb;71(2):1608–20.
Hirsch, V., et al. “A molecularly cloned, pathogenic, neutralization-resistant simian immunodeficiency virus, SIVsmE543-3.J Virol, vol. 71, no. 2, Feb. 1997, pp. 1608–20. Pubmed, doi:10.1128/JVI.71.2.1608-1620.1997.
Hirsch V, Adger-Johnson D, Campbell B, Goldstein S, Brown C, Elkins WR, Montefiori DC. A molecularly cloned, pathogenic, neutralization-resistant simian immunodeficiency virus, SIVsmE543-3. J Virol. 1997 Feb;71(2):1608–1620.

Published In

J Virol

DOI

ISSN

0022-538X

Publication Date

February 1997

Volume

71

Issue

2

Start / End Page

1608 / 1620

Location

United States

Related Subject Headings

  • Virulence
  • Virology
  • Simian immunodeficiency virus
  • Simian Immunodeficiency Virus
  • Simian Acquired Immunodeficiency Syndrome
  • Molecular Sequence Data
  • Macaca nemestrina
  • Genes, env
  • Antibodies, Viral
  • Animals