Antibody-dependent enhancement of SIV infection: further characterization and cross reactivity between macaque and sooty mangabey isolates.
Publication
, Journal Article
Montefiori, DC; Robinson, WE; Hirsch, VM; Modliszewski, A; Mitchell, WM; Johnson, PR
Published in: J Med Primatol
1990
Plasma from four rhesus macaques (Macaca mulatta), of which two were experimentally infected with the simian immunodeficiency virus (SIV) isolate SIVmac251, one with isolate SIVsmF236, and another with a SIVsmF236 molecular clone, SIVsmH-4, enhanced SIVmac infection of MT-2 cells. In addition to SIV-positive plasma, infection-enhancement required complement, CD4, and CR2. Titers of infection-enhancing antibodies appeared to correlate with disease progression. The MT-2/SIVmac251 system should be useful in future studies of complement-mediated, antibody-dependent enhancement of macaque and sooty mangabey SIV isolates.
Duke Scholars
Published In
J Med Primatol
ISSN
0047-2565
Publication Date
1990
Volume
19
Issue
3-4
Start / End Page
269 / 278
Location
Denmark
Related Subject Headings
- Virology
- Simian immunodeficiency virus
- Simian Immunodeficiency Virus
- Simian Acquired Immunodeficiency Syndrome
- Macaca mulatta
- Cross Reactions
- Complement System Proteins
- Complement Activation
- Cercopithecidae
- CD4 Antigens
Citation
APA
Chicago
ICMJE
MLA
NLM
Montefiori, D. C., Robinson, W. E., Hirsch, V. M., Modliszewski, A., Mitchell, W. M., & Johnson, P. R. (1990). Antibody-dependent enhancement of SIV infection: further characterization and cross reactivity between macaque and sooty mangabey isolates. J Med Primatol, 19(3–4), 269–278.
Montefiori, D. C., W. E. Robinson, V. M. Hirsch, A. Modliszewski, W. M. Mitchell, and P. R. Johnson. “Antibody-dependent enhancement of SIV infection: further characterization and cross reactivity between macaque and sooty mangabey isolates.” J Med Primatol 19, no. 3–4 (1990): 269–78.
Montefiori DC, Robinson WE, Hirsch VM, Modliszewski A, Mitchell WM, Johnson PR. Antibody-dependent enhancement of SIV infection: further characterization and cross reactivity between macaque and sooty mangabey isolates. J Med Primatol. 1990;19(3–4):269–78.
Montefiori, D. C., et al. “Antibody-dependent enhancement of SIV infection: further characterization and cross reactivity between macaque and sooty mangabey isolates.” J Med Primatol, vol. 19, no. 3–4, 1990, pp. 269–78.
Montefiori DC, Robinson WE, Hirsch VM, Modliszewski A, Mitchell WM, Johnson PR. Antibody-dependent enhancement of SIV infection: further characterization and cross reactivity between macaque and sooty mangabey isolates. J Med Primatol. 1990;19(3–4):269–278.
Published In
J Med Primatol
ISSN
0047-2565
Publication Date
1990
Volume
19
Issue
3-4
Start / End Page
269 / 278
Location
Denmark
Related Subject Headings
- Virology
- Simian immunodeficiency virus
- Simian Immunodeficiency Virus
- Simian Acquired Immunodeficiency Syndrome
- Macaca mulatta
- Cross Reactions
- Complement System Proteins
- Complement Activation
- Cercopithecidae
- CD4 Antigens