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Imidazo[5,1-f][1,2,4]triazin-2-amines as novel inhibitors of polo-like kinase 1.

Publication ,  Journal Article
Cheung, M; Kuntz, KW; Pobanz, M; Salovich, JM; Wilson, BJ; Andrews, CW; Shewchuk, LM; Epperly, AH; Hassler, DF; Leesnitzer, MA; Smith, JL ...
Published in: Bioorg Med Chem Lett
December 1, 2008

The synthesis and biological activities of imidazo[5,1-f][1,2,4]triazin-2-amines (imidazotriazines) as novel polo-like kinase 1 inhibitors are reported.

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Published In

Bioorg Med Chem Lett

DOI

EISSN

1464-3405

Publication Date

December 1, 2008

Volume

18

Issue

23

Start / End Page

6214 / 6217

Location

England

Related Subject Headings

  • Triazines
  • Structure-Activity Relationship
  • Proto-Oncogene Proteins
  • Protein Serine-Threonine Kinases
  • Polo-Like Kinase 1
  • Molecular Structure
  • Molecular Conformation
  • Models, Molecular
  • Mice
  • Medicinal & Biomolecular Chemistry
 

Citation

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Cheung, M., Kuntz, K. W., Pobanz, M., Salovich, J. M., Wilson, B. J., Andrews, C. W., … Mook, R. A. (2008). Imidazo[5,1-f][1,2,4]triazin-2-amines as novel inhibitors of polo-like kinase 1. Bioorg Med Chem Lett, 18(23), 6214–6217. https://doi.org/10.1016/j.bmcl.2008.09.100
Cheung, M., K. W. Kuntz, M. Pobanz, J. M. Salovich, B. J. Wilson, C. W. Andrews, L. M. Shewchuk, et al. “Imidazo[5,1-f][1,2,4]triazin-2-amines as novel inhibitors of polo-like kinase 1.Bioorg Med Chem Lett 18, no. 23 (December 1, 2008): 6214–17. https://doi.org/10.1016/j.bmcl.2008.09.100.
Cheung M, Kuntz KW, Pobanz M, Salovich JM, Wilson BJ, Andrews CW, et al. Imidazo[5,1-f][1,2,4]triazin-2-amines as novel inhibitors of polo-like kinase 1. Bioorg Med Chem Lett. 2008 Dec 1;18(23):6214–7.
Cheung, M., et al. “Imidazo[5,1-f][1,2,4]triazin-2-amines as novel inhibitors of polo-like kinase 1.Bioorg Med Chem Lett, vol. 18, no. 23, Dec. 2008, pp. 6214–17. Pubmed, doi:10.1016/j.bmcl.2008.09.100.
Cheung M, Kuntz KW, Pobanz M, Salovich JM, Wilson BJ, Andrews CW, Shewchuk LM, Epperly AH, Hassler DF, Leesnitzer MA, Smith JL, Smith GK, Lansing TJ, Mook RA. Imidazo[5,1-f][1,2,4]triazin-2-amines as novel inhibitors of polo-like kinase 1. Bioorg Med Chem Lett. 2008 Dec 1;18(23):6214–6217.
Journal cover image

Published In

Bioorg Med Chem Lett

DOI

EISSN

1464-3405

Publication Date

December 1, 2008

Volume

18

Issue

23

Start / End Page

6214 / 6217

Location

England

Related Subject Headings

  • Triazines
  • Structure-Activity Relationship
  • Proto-Oncogene Proteins
  • Protein Serine-Threonine Kinases
  • Polo-Like Kinase 1
  • Molecular Structure
  • Molecular Conformation
  • Models, Molecular
  • Mice
  • Medicinal & Biomolecular Chemistry