Synthesis and biological activity of a novel series of indole-derived PPARgamma agonists.
Publication
, Journal Article
Henke, BR; Adkison, KK; Blanchard, SG; Leesnitzer, LM; Mook, RA; Plunket, KD; Ray, JA; Roberson, C; Unwalla, R; Willson, TM
Published in: Bioorg Med Chem Lett
December 6, 1999
The synthesis and structure-activity relationships of a novel series of indole 5-carboxylic acids that bind and activate peroxisome proliferator-activated receptor gamma (PPARgamma) are reported. These new analogs are selective for PPARgamma vs the other PPAR subtypes, and the most potent compounds in this series are comparable to in vitro potencies at PPARgamma reported for the thiazolidinedione-based antidiabetic drugs currently in clinical use.
Duke Scholars
Altmetric Attention Stats
Dimensions Citation Stats
Published In
Bioorg Med Chem Lett
DOI
ISSN
0960-894X
Publication Date
December 6, 1999
Volume
9
Issue
23
Start / End Page
3329 / 3334
Location
England
Related Subject Headings
- Transcription Factors
- Structure-Activity Relationship
- Receptors, Cytoplasmic and Nuclear
- Rats
- Medicinal & Biomolecular Chemistry
- Indoles
- Humans
- Biological Availability
- Animals
- 3405 Organic chemistry
Citation
APA
Chicago
ICMJE
MLA
NLM
Henke, B. R., Adkison, K. K., Blanchard, S. G., Leesnitzer, L. M., Mook, R. A., Plunket, K. D., … Willson, T. M. (1999). Synthesis and biological activity of a novel series of indole-derived PPARgamma agonists. Bioorg Med Chem Lett, 9(23), 3329–3334. https://doi.org/10.1016/s0960-894x(99)00603-4
Henke, B. R., K. K. Adkison, S. G. Blanchard, L. M. Leesnitzer, R. A. Mook, K. D. Plunket, J. A. Ray, C. Roberson, R. Unwalla, and T. M. Willson. “Synthesis and biological activity of a novel series of indole-derived PPARgamma agonists.” Bioorg Med Chem Lett 9, no. 23 (December 6, 1999): 3329–34. https://doi.org/10.1016/s0960-894x(99)00603-4.
Henke BR, Adkison KK, Blanchard SG, Leesnitzer LM, Mook RA, Plunket KD, et al. Synthesis and biological activity of a novel series of indole-derived PPARgamma agonists. Bioorg Med Chem Lett. 1999 Dec 6;9(23):3329–34.
Henke, B. R., et al. “Synthesis and biological activity of a novel series of indole-derived PPARgamma agonists.” Bioorg Med Chem Lett, vol. 9, no. 23, Dec. 1999, pp. 3329–34. Pubmed, doi:10.1016/s0960-894x(99)00603-4.
Henke BR, Adkison KK, Blanchard SG, Leesnitzer LM, Mook RA, Plunket KD, Ray JA, Roberson C, Unwalla R, Willson TM. Synthesis and biological activity of a novel series of indole-derived PPARgamma agonists. Bioorg Med Chem Lett. 1999 Dec 6;9(23):3329–3334.
Published In
Bioorg Med Chem Lett
DOI
ISSN
0960-894X
Publication Date
December 6, 1999
Volume
9
Issue
23
Start / End Page
3329 / 3334
Location
England
Related Subject Headings
- Transcription Factors
- Structure-Activity Relationship
- Receptors, Cytoplasmic and Nuclear
- Rats
- Medicinal & Biomolecular Chemistry
- Indoles
- Humans
- Biological Availability
- Animals
- 3405 Organic chemistry