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Synthesis of phenanthridin-3-one derivatives: Non-steroidal inhibitors of steroid 5-α-reductase

Publication ,  Journal Article
Mook, RA; Lackey, K; Bennett, C
Published in: Tetrahedron Letters
June 5, 1995

A short and efficient six-step synthesis of novel phenanthridin-3-one derivatives is described. The synthesis of these derivatives is highlighted by the cyclization of a suitably placed ketone side chain with a thioiminium ion. The derivatives prepared were found to be inhibitors of human steroid 5-α-reductase. © 1995.

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Published In

Tetrahedron Letters

DOI

ISSN

0040-4039

Publication Date

June 5, 1995

Volume

36

Issue

23

Start / End Page

3969 / 3972

Related Subject Headings

  • Organic Chemistry
  • 0305 Organic Chemistry
  • 0304 Medicinal and Biomolecular Chemistry
 

Citation

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Mook, R. A., Lackey, K., & Bennett, C. (1995). Synthesis of phenanthridin-3-one derivatives: Non-steroidal inhibitors of steroid 5-α-reductase. Tetrahedron Letters, 36(23), 3969–3972. https://doi.org/10.1016/0040-4039(95)00690-E
Mook, R. A., K. Lackey, and C. Bennett. “Synthesis of phenanthridin-3-one derivatives: Non-steroidal inhibitors of steroid 5-α-reductase.” Tetrahedron Letters 36, no. 23 (June 5, 1995): 3969–72. https://doi.org/10.1016/0040-4039(95)00690-E.
Mook RA, Lackey K, Bennett C. Synthesis of phenanthridin-3-one derivatives: Non-steroidal inhibitors of steroid 5-α-reductase. Tetrahedron Letters. 1995 Jun 5;36(23):3969–72.
Mook, R. A., et al. “Synthesis of phenanthridin-3-one derivatives: Non-steroidal inhibitors of steroid 5-α-reductase.” Tetrahedron Letters, vol. 36, no. 23, June 1995, pp. 3969–72. Scopus, doi:10.1016/0040-4039(95)00690-E.
Mook RA, Lackey K, Bennett C. Synthesis of phenanthridin-3-one derivatives: Non-steroidal inhibitors of steroid 5-α-reductase. Tetrahedron Letters. 1995 Jun 5;36(23):3969–3972.
Journal cover image

Published In

Tetrahedron Letters

DOI

ISSN

0040-4039

Publication Date

June 5, 1995

Volume

36

Issue

23

Start / End Page

3969 / 3972

Related Subject Headings

  • Organic Chemistry
  • 0305 Organic Chemistry
  • 0304 Medicinal and Biomolecular Chemistry