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Differences in prognostic factors and outcomes in African Americans and whites with acute myeloid leukemia.

Publication ,  Journal Article
Sekeres, MA; Peterson, B; Dodge, RK; Mayer, RJ; Moore, JO; Lee, EJ; Kolitz, J; Baer, MR; Schiffer, CA; Carroll, AJ; Vardiman, JW; Davey, FR ...
Published in: Blood
June 1, 2004

Whites have a more favorable prognosis than African Americans for a number of cancers. The relationship between race and outcome is less clear in acute myeloid leukemia (AML). Using data from 7 Cancer and Leukemia Group B studies initiated from 1985 to 1997, we conducted a retrospective cross-sectional analysis of 2570 patients (270 African American and 2300 white) with de novo AML who received induction chemotherapy. African Americans were younger than whites (48 versus 54 years, P <.001). African Americans also had different cytogenetic risk group distributions than whites (P <.001): they were more commonly classified in the favorable (23% versus 14%) and unfavorable (31% versus 23%) groups, and less commonly classified in the intermediate group (47% versus 63%). African American men had a lower complete remission (CR) rate (54%, compared with 64% for white men, 65% for white women, and 70% for African American women, P =.001) and a worse overall survival compared with all other patients (P =.004), when known risk factors are taken into account. African Americans and whites with AML differ with respect to important prognostic factors. African American men have worse CR rates and overall survival than whites and African American women, and should be considered a poor-risk group.

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Published In

Blood

DOI

ISSN

0006-4971

Publication Date

June 1, 2004

Volume

103

Issue

11

Start / End Page

4036 / 4042

Location

United States

Related Subject Headings

  • White People
  • Treatment Outcome
  • Risk Factors
  • Retrospective Studies
  • Remission Induction
  • Prognosis
  • Middle Aged
  • Male
  • Leukemia, Myeloid
  • Immunology
 

Citation

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Sekeres, M. A., Peterson, B., Dodge, R. K., Mayer, R. J., Moore, J. O., Lee, E. J., … Cancer and Leukemia Group B, . (2004). Differences in prognostic factors and outcomes in African Americans and whites with acute myeloid leukemia. Blood, 103(11), 4036–4042. https://doi.org/10.1182/blood-2003-09-3118
Sekeres, Mikkael A., Bercedis Peterson, Richard K. Dodge, Robert J. Mayer, Joseph O. Moore, Edward J. Lee, Jonathan Kolitz, et al. “Differences in prognostic factors and outcomes in African Americans and whites with acute myeloid leukemia.Blood 103, no. 11 (June 1, 2004): 4036–42. https://doi.org/10.1182/blood-2003-09-3118.
Sekeres MA, Peterson B, Dodge RK, Mayer RJ, Moore JO, Lee EJ, et al. Differences in prognostic factors and outcomes in African Americans and whites with acute myeloid leukemia. Blood. 2004 Jun 1;103(11):4036–42.
Sekeres, Mikkael A., et al. “Differences in prognostic factors and outcomes in African Americans and whites with acute myeloid leukemia.Blood, vol. 103, no. 11, June 2004, pp. 4036–42. Pubmed, doi:10.1182/blood-2003-09-3118.
Sekeres MA, Peterson B, Dodge RK, Mayer RJ, Moore JO, Lee EJ, Kolitz J, Baer MR, Schiffer CA, Carroll AJ, Vardiman JW, Davey FR, Bloomfield CD, Larson RA, Stone RM, Cancer and Leukemia Group B. Differences in prognostic factors and outcomes in African Americans and whites with acute myeloid leukemia. Blood. 2004 Jun 1;103(11):4036–4042.

Published In

Blood

DOI

ISSN

0006-4971

Publication Date

June 1, 2004

Volume

103

Issue

11

Start / End Page

4036 / 4042

Location

United States

Related Subject Headings

  • White People
  • Treatment Outcome
  • Risk Factors
  • Retrospective Studies
  • Remission Induction
  • Prognosis
  • Middle Aged
  • Male
  • Leukemia, Myeloid
  • Immunology