Somatostatin augments the M-current in hippocampal neurons.
Publication
, Journal Article
Moore, SD; Madamba, SG; Joëls, M; Siggins, GR
Published in: Science
January 15, 1988
Immunocytochemical and electrophysiological evidence suggests that somatostatin may be a transmitter in the hippocampus. To characterize the ionic mechanisms underlying somatostatin effects, voltage-clamp and current-clamp studies on single CA1 pyramidal neurons in the hippocampal slice preparation were performed. Both somatostatin-28 and somatostatin-14 elicited a steady outward current and selectively augmented the noninactivating, voltage-dependent outward potassium current known as the M-current. Since the muscarinic cholinergic agonists carbachol and muscarine antagonized this current, these results suggest a reciprocal regulation of the M-current by somatostatin and acetylcholine.
Duke Scholars
Published In
Science
DOI
ISSN
0036-8075
Publication Date
January 15, 1988
Volume
239
Issue
4837
Start / End Page
278 / 280
Location
United States
Related Subject Headings
- Somatostatin-28
- Somatostatin
- Rats
- Potassium
- Neurons
- Muscarine
- Membrane Potentials
- Hippocampus
- General Science & Technology
- Electric Conductivity
Citation
APA
Chicago
ICMJE
MLA
NLM
Moore, S. D., Madamba, S. G., Joëls, M., & Siggins, G. R. (1988). Somatostatin augments the M-current in hippocampal neurons. Science, 239(4837), 278–280. https://doi.org/10.1126/science.2892268
Moore, S. D., S. G. Madamba, M. Joëls, and G. R. Siggins. “Somatostatin augments the M-current in hippocampal neurons.” Science 239, no. 4837 (January 15, 1988): 278–80. https://doi.org/10.1126/science.2892268.
Moore SD, Madamba SG, Joëls M, Siggins GR. Somatostatin augments the M-current in hippocampal neurons. Science. 1988 Jan 15;239(4837):278–80.
Moore, S. D., et al. “Somatostatin augments the M-current in hippocampal neurons.” Science, vol. 239, no. 4837, Jan. 1988, pp. 278–80. Pubmed, doi:10.1126/science.2892268.
Moore SD, Madamba SG, Joëls M, Siggins GR. Somatostatin augments the M-current in hippocampal neurons. Science. 1988 Jan 15;239(4837):278–280.
Published In
Science
DOI
ISSN
0036-8075
Publication Date
January 15, 1988
Volume
239
Issue
4837
Start / End Page
278 / 280
Location
United States
Related Subject Headings
- Somatostatin-28
- Somatostatin
- Rats
- Potassium
- Neurons
- Muscarine
- Membrane Potentials
- Hippocampus
- General Science & Technology
- Electric Conductivity