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Enkephalin analogues depress synaptic potentials in rat dentate granule cells recorded intracellularly in vitro.

Publication ,  Journal Article
Moore, SD; Madamba, SG; Zieglgänsberger, W; Siggins, GR
Published in: Neurosci Lett
August 15, 1988

Enkephalin analogues were superfused onto hippocampal slices during intracellular recording of dentate granule cells. The enkephalins elicited either weak depolarizations, weak hyperpolarizations, or no effect on membrane potential, in about equal numbers of cells tested. Similarly, input resistance either decreased, increased or did not change, and was not well correlated with the potential changes. However, at all concentrations tested (2-10 microM) the enkephalins reduced evoked depolarizing synaptic potentials by up to 70%. We speculate that a major function of endogenous enkephalin-containing fibers projecting to the dentate is to dampen afferent synaptic transmission.

Duke Scholars

Published In

Neurosci Lett

DOI

ISSN

0304-3940

Publication Date

August 15, 1988

Volume

91

Issue

1

Start / End Page

71 / 76

Location

Ireland

Related Subject Headings

  • Rats, Inbred Strains
  • Rats
  • Naloxone
  • Male
  • In Vitro Techniques
  • Hippocampus
  • Enkephalin, Methionine
  • Enkephalin, Leucine-2-Alanine
  • Enkephalin, Leucine
  • Animals
 

Citation

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Moore, S. D., Madamba, S. G., Zieglgänsberger, W., & Siggins, G. R. (1988). Enkephalin analogues depress synaptic potentials in rat dentate granule cells recorded intracellularly in vitro. Neurosci Lett, 91(1), 71–76. https://doi.org/10.1016/0304-3940(88)90251-0
Moore, S. D., S. G. Madamba, W. Zieglgänsberger, and G. R. Siggins. “Enkephalin analogues depress synaptic potentials in rat dentate granule cells recorded intracellularly in vitro.Neurosci Lett 91, no. 1 (August 15, 1988): 71–76. https://doi.org/10.1016/0304-3940(88)90251-0.
Moore SD, Madamba SG, Zieglgänsberger W, Siggins GR. Enkephalin analogues depress synaptic potentials in rat dentate granule cells recorded intracellularly in vitro. Neurosci Lett. 1988 Aug 15;91(1):71–6.
Moore, S. D., et al. “Enkephalin analogues depress synaptic potentials in rat dentate granule cells recorded intracellularly in vitro.Neurosci Lett, vol. 91, no. 1, Aug. 1988, pp. 71–76. Pubmed, doi:10.1016/0304-3940(88)90251-0.
Moore SD, Madamba SG, Zieglgänsberger W, Siggins GR. Enkephalin analogues depress synaptic potentials in rat dentate granule cells recorded intracellularly in vitro. Neurosci Lett. 1988 Aug 15;91(1):71–76.
Journal cover image

Published In

Neurosci Lett

DOI

ISSN

0304-3940

Publication Date

August 15, 1988

Volume

91

Issue

1

Start / End Page

71 / 76

Location

Ireland

Related Subject Headings

  • Rats, Inbred Strains
  • Rats
  • Naloxone
  • Male
  • In Vitro Techniques
  • Hippocampus
  • Enkephalin, Methionine
  • Enkephalin, Leucine-2-Alanine
  • Enkephalin, Leucine
  • Animals