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Neural systems for cognitive and emotional processing in posttraumatic stress disorder.

Publication ,  Journal Article
Brown, VM; Morey, RA
Published in: Front Psychol
2012

Individuals with posttraumatic stress disorder (PTSD) show altered cognition when trauma-related material is present. PTSD may lead to enhanced processing of trauma-related material, or it may cause impaired processing of trauma-unrelated information. However, other forms of emotional information may also alter cognition in PTSD. In this review, we discuss the behavioral and neural effects of emotion processing on cognition in PTSD, with a focus on neuroimaging results. We propose a model of emotion-cognition interaction based on evidence of two network models of altered brain activation in PTSD. The first is a trauma-disrupted network made up of ventrolateral PFC, dorsal anterior cingulate cortex (ACC), hippocampus, insula, and dorsomedial PFC that are differentially modulated by trauma content relative to emotional trauma-unrelated information. The trauma-disrupted network forms a subnetwork of regions within a larger, widely recognized network organized into ventral and dorsal streams for processing emotional and cognitive information that converge in the medial PFC and cingulate cortex. Models of fear learning, while not a cognitive process in the conventional sense, provide important insights into the maintenance of the core symptom clusters of PTSD such as re-experiencing and hypervigilance. Fear processing takes place within the limbic corticostriatal loop composed of threat-alerting and threat-assessing components. Understanding the disruptions in these two networks, and their effect on individuals with PTSD, will lead to an improved knowledge of the etiopathogenesis of PTSD and potential targets for both psychotherapeutic and pharmacotherapeutic interventions.

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Published In

Front Psychol

DOI

EISSN

1664-1078

Publication Date

2012

Volume

3

Start / End Page

449

Location

Switzerland

Related Subject Headings

  • 52 Psychology
  • 32 Biomedical and clinical sciences
  • 1702 Cognitive Sciences
  • 1701 Psychology
 

Citation

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ICMJE
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Brown, V. M., & Morey, R. A. (2012). Neural systems for cognitive and emotional processing in posttraumatic stress disorder. Front Psychol, 3, 449. https://doi.org/10.3389/fpsyg.2012.00449
Brown, Vanessa M., and Rajendra A. Morey. “Neural systems for cognitive and emotional processing in posttraumatic stress disorder.Front Psychol 3 (2012): 449. https://doi.org/10.3389/fpsyg.2012.00449.
Brown, Vanessa M., and Rajendra A. Morey. “Neural systems for cognitive and emotional processing in posttraumatic stress disorder.Front Psychol, vol. 3, 2012, p. 449. Pubmed, doi:10.3389/fpsyg.2012.00449.

Published In

Front Psychol

DOI

EISSN

1664-1078

Publication Date

2012

Volume

3

Start / End Page

449

Location

Switzerland

Related Subject Headings

  • 52 Psychology
  • 32 Biomedical and clinical sciences
  • 1702 Cognitive Sciences
  • 1701 Psychology