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Engineering DNA vaccines via co-delivery of co-stimulatory molecule genes.

Publication ,  Journal Article
Kim, JJ; Nottingham, LK; Wilson, DM; Bagarazzi, ML; Tsai, A; Morrison, LD; Javadian, A; Chalian, AA; Agadjanyan, MG; Weiner, DB
Published in: Vaccine
November 1998

DNA immunization has been investigated as a potential immunization strategy against infectious diseases and cancer. To enhance a DNA vaccine's ability to induce CTL response in vivo, we co-administered CD80 and CD86 expression cassettes along with HIV-1 immunogens. This manipulation resulted in a dramatic increase in MHC class I-restricted and CD8+ T-cell-dependent CTL responses in both mice and chimpanzees. This strategy of engineering vaccine producing cells to be more efficient T-cell activators could be an important tool for optimizing antigen-specific T-cell-mediated immune responses in the pursuit of more rationally designed vaccines and immune therapies.

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Published In

Vaccine

DOI

ISSN

0264-410X

Publication Date

November 1998

Volume

16

Issue

19

Start / End Page

1828 / 1835

Location

Netherlands

Related Subject Headings

  • Virology
  • Vaccines, DNA
  • T-Lymphocytes, Helper-Inducer
  • T-Lymphocytes, Cytotoxic
  • Pan troglodytes
  • Molecular Sequence Data
  • Mice, Inbred BALB C
  • Mice
  • Membrane Glycoproteins
  • Lymphokines
 

Citation

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Kim, J. J., Nottingham, L. K., Wilson, D. M., Bagarazzi, M. L., Tsai, A., Morrison, L. D., … Weiner, D. B. (1998). Engineering DNA vaccines via co-delivery of co-stimulatory molecule genes. Vaccine, 16(19), 1828–1835. https://doi.org/10.1016/s0264-410x(98)00177-7
Kim, J. J., L. K. Nottingham, D. M. Wilson, M. L. Bagarazzi, A. Tsai, L. D. Morrison, A. Javadian, A. A. Chalian, M. G. Agadjanyan, and D. B. Weiner. “Engineering DNA vaccines via co-delivery of co-stimulatory molecule genes.Vaccine 16, no. 19 (November 1998): 1828–35. https://doi.org/10.1016/s0264-410x(98)00177-7.
Kim JJ, Nottingham LK, Wilson DM, Bagarazzi ML, Tsai A, Morrison LD, et al. Engineering DNA vaccines via co-delivery of co-stimulatory molecule genes. Vaccine. 1998 Nov;16(19):1828–35.
Kim, J. J., et al. “Engineering DNA vaccines via co-delivery of co-stimulatory molecule genes.Vaccine, vol. 16, no. 19, Nov. 1998, pp. 1828–35. Pubmed, doi:10.1016/s0264-410x(98)00177-7.
Kim JJ, Nottingham LK, Wilson DM, Bagarazzi ML, Tsai A, Morrison LD, Javadian A, Chalian AA, Agadjanyan MG, Weiner DB. Engineering DNA vaccines via co-delivery of co-stimulatory molecule genes. Vaccine. 1998 Nov;16(19):1828–1835.
Journal cover image

Published In

Vaccine

DOI

ISSN

0264-410X

Publication Date

November 1998

Volume

16

Issue

19

Start / End Page

1828 / 1835

Location

Netherlands

Related Subject Headings

  • Virology
  • Vaccines, DNA
  • T-Lymphocytes, Helper-Inducer
  • T-Lymphocytes, Cytotoxic
  • Pan troglodytes
  • Molecular Sequence Data
  • Mice, Inbred BALB C
  • Mice
  • Membrane Glycoproteins
  • Lymphokines