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Potential donor-recipient MYH9 genotype interactions in posttransplant nephrotic syndrome after pediatric kidney transplantation.

Publication ,  Journal Article
Freedman, BI; Nagaraj, SK; Lin, J-J; Gautreaux, MD; Bowden, DW; Iskandar, SS; Stratta, RJ; Rogers, J; Hartmann, EL; Farney, AC; Reeves-Daniel, AM
Published in: Am J Transplant
October 2009

Recurrence of focal segmental glomerulosclerosis (FSGS) with nephrotic syndrome is relatively common after kidney transplantation in young recipients whose predialysis course consists of heavy proteinuria, hypertension and subacute loss of kidney function. The gene(s) mediating this effect remain unknown. We report an unusual circumstance where kidneys recovered from a deceased African American male donor with MYH9-related occult FSGS (risk variants in seven of eight MYH9 E1 haplotype single nucleotide polymorphisms) were transplanted into an African American male child with risk variants in four MYH9 E1 risk variants and a European American female teenager with two MYH9 E1 risk variants. Fulminant nephrotic syndrome rapidly developed in the African American recipient, whereas the European American had an uneventful posttransplant course. The kidney donor lacked significant proteinuria at the time of organ procurement. This scenario suggests that donor-recipient interactions in MYH9, as well as other gene-gene and gene-environment interactions, may lead to recurrent nephrotic syndrome after renal transplantation. The impact of transplanting kidneys from donors with multiple MYH9 risk alleles into recipients with similar genetic background at high risk for recurrent kidney disease needs to be determined.

Duke Scholars

Published In

Am J Transplant

DOI

EISSN

1600-6143

Publication Date

October 2009

Volume

9

Issue

10

Start / End Page

2435 / 2440

Location

United States

Related Subject Headings

  • Surgery
  • Nephrotic Syndrome
  • Myosin Heavy Chains
  • Molecular Motor Proteins
  • Male
  • Kidney Transplantation
  • Humans
  • Haplotypes
  • Genotype
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
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Freedman, B. I., Nagaraj, S. K., Lin, J.-J., Gautreaux, M. D., Bowden, D. W., Iskandar, S. S., … Reeves-Daniel, A. M. (2009). Potential donor-recipient MYH9 genotype interactions in posttransplant nephrotic syndrome after pediatric kidney transplantation. Am J Transplant, 9(10), 2435–2440. https://doi.org/10.1111/j.1600-6143.2009.02806.x
Freedman, B. I., S. K. Nagaraj, J. -. J. Lin, M. D. Gautreaux, D. W. Bowden, S. S. Iskandar, R. J. Stratta, et al. “Potential donor-recipient MYH9 genotype interactions in posttransplant nephrotic syndrome after pediatric kidney transplantation.Am J Transplant 9, no. 10 (October 2009): 2435–40. https://doi.org/10.1111/j.1600-6143.2009.02806.x.
Freedman BI, Nagaraj SK, Lin J-J, Gautreaux MD, Bowden DW, Iskandar SS, et al. Potential donor-recipient MYH9 genotype interactions in posttransplant nephrotic syndrome after pediatric kidney transplantation. Am J Transplant. 2009 Oct;9(10):2435–40.
Freedman, B. I., et al. “Potential donor-recipient MYH9 genotype interactions in posttransplant nephrotic syndrome after pediatric kidney transplantation.Am J Transplant, vol. 9, no. 10, Oct. 2009, pp. 2435–40. Pubmed, doi:10.1111/j.1600-6143.2009.02806.x.
Freedman BI, Nagaraj SK, Lin J-J, Gautreaux MD, Bowden DW, Iskandar SS, Stratta RJ, Rogers J, Hartmann EL, Farney AC, Reeves-Daniel AM. Potential donor-recipient MYH9 genotype interactions in posttransplant nephrotic syndrome after pediatric kidney transplantation. Am J Transplant. 2009 Oct;9(10):2435–2440.
Journal cover image

Published In

Am J Transplant

DOI

EISSN

1600-6143

Publication Date

October 2009

Volume

9

Issue

10

Start / End Page

2435 / 2440

Location

United States

Related Subject Headings

  • Surgery
  • Nephrotic Syndrome
  • Myosin Heavy Chains
  • Molecular Motor Proteins
  • Male
  • Kidney Transplantation
  • Humans
  • Haplotypes
  • Genotype
  • Female