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Protein translocation in the endoplasmic reticulum: The search for a unified molecular mechanism

Publication ,  Journal Article
Nicchitta, CV
Published in: Seminars in Cell and Developmental Biology
January 1, 1996

The development of procedures for the reconstitution of protein translocation in the endoplasmic reticulum (ER) has allowed substantial new insights into the molecular mechanism of translocation. With these techniques, investigators are beginning to address the functional role of individual membrane and lumenal protein components in translocation. Efforts are now focused on the functional analysis of the translocation channel, the regulation of ribosome binding and the role of molecular chaperones in vectorial transport across the lipid bilayer. Current models of translocation suggest a system of remarkable simplicity; the molecular mechanism of translocation, however, remains elusive. ©1996 Academic Press Ltd.

Duke Scholars

Published In

Seminars in Cell and Developmental Biology

DOI

ISSN

1084-9521

Publication Date

January 1, 1996

Volume

7

Issue

4

Start / End Page

497 / 503

Related Subject Headings

  • Developmental Biology
  • 3101 Biochemistry and cell biology
  • 1114 Paediatrics and Reproductive Medicine
  • 0601 Biochemistry and Cell Biology
 

Citation

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MLA
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Nicchitta, C. V. (1996). Protein translocation in the endoplasmic reticulum: The search for a unified molecular mechanism. Seminars in Cell and Developmental Biology, 7(4), 497–503. https://doi.org/10.1006/scdb.1996.0062
Nicchitta, C. V. “Protein translocation in the endoplasmic reticulum: The search for a unified molecular mechanism.” Seminars in Cell and Developmental Biology 7, no. 4 (January 1, 1996): 497–503. https://doi.org/10.1006/scdb.1996.0062.
Nicchitta CV. Protein translocation in the endoplasmic reticulum: The search for a unified molecular mechanism. Seminars in Cell and Developmental Biology. 1996 Jan 1;7(4):497–503.
Nicchitta, C. V. “Protein translocation in the endoplasmic reticulum: The search for a unified molecular mechanism.” Seminars in Cell and Developmental Biology, vol. 7, no. 4, Jan. 1996, pp. 497–503. Scopus, doi:10.1006/scdb.1996.0062.
Nicchitta CV. Protein translocation in the endoplasmic reticulum: The search for a unified molecular mechanism. Seminars in Cell and Developmental Biology. 1996 Jan 1;7(4):497–503.
Journal cover image

Published In

Seminars in Cell and Developmental Biology

DOI

ISSN

1084-9521

Publication Date

January 1, 1996

Volume

7

Issue

4

Start / End Page

497 / 503

Related Subject Headings

  • Developmental Biology
  • 3101 Biochemistry and cell biology
  • 1114 Paediatrics and Reproductive Medicine
  • 0601 Biochemistry and Cell Biology