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Spatiotemporal coupling between hippocampal acetylcholine release and theta oscillations in vivo.

Publication ,  Journal Article
Zhang, H; Lin, S-C; Nicolelis, MAL
Published in: J Neurosci
October 6, 2010

Both acetylcholine (ACh) and theta oscillations are important for learning and memory, but the dynamic interaction between these two processes remains unclear. Recent advances in amperometry techniques have revealed phasic ACh releases in vivo. However, it is unknown whether phasic ACh release co-occurs with theta oscillations. We investigated this issue in the CA1 region of urethane-anesthetized male rats using amperometric and electrophysiological recordings. We found that ACh release was highly correlated with the appearance of both spontaneous and induced theta oscillations. Moreover, the maximal ACh release was observed around or slightly above the pyramidal layer. Interestingly, such release lagged behind theta initiation by 25-60 s. The slow ACh release profile was matched by the slow firing rate increase of a subset of medial-septal low-firing-rate neurons. Together, these results establish, for the first time, the in vivo coupling between phasic ACh release and theta oscillations on spatiotemporal scales much finer than previously known. These findings also suggest that phasic ACh is not required for theta initiation and may instead operate synergistically with theta oscillations to promote neural plasticity in the service of learning and memory.

Duke Scholars

Published In

J Neurosci

DOI

EISSN

1529-2401

Publication Date

October 6, 2010

Volume

30

Issue

40

Start / End Page

13431 / 13440

Location

United States

Related Subject Headings

  • Theta Rhythm
  • Synaptic Transmission
  • Reaction Time
  • Rats, Long-Evans
  • Rats
  • Pyramidal Cells
  • Neurons
  • Neuronal Plasticity
  • Neurology & Neurosurgery
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Zhang, H., Lin, S.-C., & Nicolelis, M. A. L. (2010). Spatiotemporal coupling between hippocampal acetylcholine release and theta oscillations in vivo. J Neurosci, 30(40), 13431–13440. https://doi.org/10.1523/JNEUROSCI.1144-10.2010
Zhang, Hao, Shih-Chieh Lin, and Miguel A. L. Nicolelis. “Spatiotemporal coupling between hippocampal acetylcholine release and theta oscillations in vivo.J Neurosci 30, no. 40 (October 6, 2010): 13431–40. https://doi.org/10.1523/JNEUROSCI.1144-10.2010.
Zhang H, Lin S-C, Nicolelis MAL. Spatiotemporal coupling between hippocampal acetylcholine release and theta oscillations in vivo. J Neurosci. 2010 Oct 6;30(40):13431–40.
Zhang, Hao, et al. “Spatiotemporal coupling between hippocampal acetylcholine release and theta oscillations in vivo.J Neurosci, vol. 30, no. 40, Oct. 2010, pp. 13431–40. Pubmed, doi:10.1523/JNEUROSCI.1144-10.2010.
Zhang H, Lin S-C, Nicolelis MAL. Spatiotemporal coupling between hippocampal acetylcholine release and theta oscillations in vivo. J Neurosci. 2010 Oct 6;30(40):13431–13440.

Published In

J Neurosci

DOI

EISSN

1529-2401

Publication Date

October 6, 2010

Volume

30

Issue

40

Start / End Page

13431 / 13440

Location

United States

Related Subject Headings

  • Theta Rhythm
  • Synaptic Transmission
  • Reaction Time
  • Rats, Long-Evans
  • Rats
  • Pyramidal Cells
  • Neurons
  • Neuronal Plasticity
  • Neurology & Neurosurgery
  • Male