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Primate reaching cued by multichannel spatiotemporal cortical microstimulation.

Publication ,  Journal Article
Fitzsimmons, NA; Drake, W; Hanson, TL; Lebedev, MA; Nicolelis, MAL
Published in: J Neurosci
May 23, 2007

Both humans and animals can discriminate signals delivered to sensory areas of their brains using electrical microstimulation. This opens the possibility of creating an artificial sensory channel that could be implemented in neuroprosthetic devices. Although microstimulation delivered through multiple implanted electrodes could be beneficial for this purpose, appropriate microstimulation protocols have not been developed. Here, we report a series of experiments in which owl monkeys performed reaching movements guided by spatiotemporal patterns of cortical microstimulation delivered to primary somatosensory cortex through chronically implanted multielectrode arrays. The monkeys learned to discriminate microstimulation patterns, and their ability to learn new patterns and new behavioral rules improved during several months of testing. Significantly, information was conveyed to the brain through the interplay of microstimulation patterns delivered to multiple electrodes and the temporal order in which these electrodes were stimulated. This suggests multichannel microstimulation as a viable means of sensorizing neural prostheses.

Duke Scholars

Published In

J Neurosci

DOI

EISSN

1529-2401

Publication Date

May 23, 2007

Volume

27

Issue

21

Start / End Page

5593 / 5602

Location

United States

Related Subject Headings

  • Somatosensory Cortex
  • Neurology & Neurosurgery
  • Movement
  • Motor Skills
  • Microelectrodes
  • Female
  • Electrodes, Implanted
  • Electric Stimulation
  • Cues
  • Aotidae
 

Citation

APA
Chicago
ICMJE
MLA
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Fitzsimmons, N. A., Drake, W., Hanson, T. L., Lebedev, M. A., & Nicolelis, M. A. L. (2007). Primate reaching cued by multichannel spatiotemporal cortical microstimulation. J Neurosci, 27(21), 5593–5602. https://doi.org/10.1523/JNEUROSCI.5297-06.2007
Fitzsimmons, N. A., W. Drake, T. L. Hanson, M. A. Lebedev, and M. A. L. Nicolelis. “Primate reaching cued by multichannel spatiotemporal cortical microstimulation.J Neurosci 27, no. 21 (May 23, 2007): 5593–5602. https://doi.org/10.1523/JNEUROSCI.5297-06.2007.
Fitzsimmons NA, Drake W, Hanson TL, Lebedev MA, Nicolelis MAL. Primate reaching cued by multichannel spatiotemporal cortical microstimulation. J Neurosci. 2007 May 23;27(21):5593–602.
Fitzsimmons, N. A., et al. “Primate reaching cued by multichannel spatiotemporal cortical microstimulation.J Neurosci, vol. 27, no. 21, May 2007, pp. 5593–602. Pubmed, doi:10.1523/JNEUROSCI.5297-06.2007.
Fitzsimmons NA, Drake W, Hanson TL, Lebedev MA, Nicolelis MAL. Primate reaching cued by multichannel spatiotemporal cortical microstimulation. J Neurosci. 2007 May 23;27(21):5593–5602.

Published In

J Neurosci

DOI

EISSN

1529-2401

Publication Date

May 23, 2007

Volume

27

Issue

21

Start / End Page

5593 / 5602

Location

United States

Related Subject Headings

  • Somatosensory Cortex
  • Neurology & Neurosurgery
  • Movement
  • Motor Skills
  • Microelectrodes
  • Female
  • Electrodes, Implanted
  • Electric Stimulation
  • Cues
  • Aotidae