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Dietary glycemic load and cancer recurrence and survival in patients with stage III colon cancer: findings from CALGB 89803.

Publication ,  Journal Article
Meyerhardt, JA; Sato, K; Niedzwiecki, D; Ye, C; Saltz, LB; Mayer, RJ; Mowat, RB; Whittom, R; Hantel, A; Benson, A; Wigler, DS; Venook, A; Fuchs, CS
Published in: J Natl Cancer Inst
November 21, 2012

BACKGROUND: The influence of glycemic load and related measures on survival among colon cancer patients remains largely unknown. METHODS: We conducted a prospective, observational study of 1011 stage III colon cancer patients reporting dietary intake during and 6 months after participation in an adjuvant chemotherapy trial. We examined the influence of glycemic load, glycemic index, fructose, and carbohydrate intakes on cancer recurrence and mortality using Cox proportional hazards regression; all tests of statistical significance were two-sided. RESULTS: Stage III colon cancer patients in the highest quintile of dietary glycemic load experienced an adjusted hazard ratio (HR) for disease-free survival of 1.79 (95% confidence interval [CI] = 1.29 to 2.48), compared with those in the lowest quintile (P (trend) across quintiles <.001). Increased glycemic load was associated with similar detriments in recurrence-free (P (trend) across quintiles <.001) and overall survival (P (trend) across quintiles <.001). These associations differed statistically significant by body mass index (BMI) (P (interaction) =.01). Whereas glycemic load was not associated with disease-free survival in patients with BMI < 25kg/m(2), higher glycemic load was statistically significant associated with worse disease-free survival among overweight or obese participants (BMI ≥ 25kg/m(2); HR = 2.26; 95% CI = 1.53 to 3.32; P (trend) across quintiles <.001). Increasing total carbohydrate intake was similarly associated with inferior disease-free, recurrence-free, and overall survival (P (trend) across quintiles <.001). CONCLUSION: Higher dietary glycemic load and total carbohydrate intake were statistically significant associated with an increased risk of recurrence and mortality in stage III colon cancer patients. These findings support the role of energy balance factors in colon cancer progression and may offer potential opportunities to improve patient survival.

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Published In

J Natl Cancer Inst

DOI

EISSN

1460-2105

Publication Date

November 21, 2012

Volume

104

Issue

22

Start / End Page

1702 / 1711

Location

United States

Related Subject Headings

  • United States
  • Survival Analysis
  • Risk Factors
  • Randomized Controlled Trials as Topic
  • Prospective Studies
  • Proportional Hazards Models
  • Oncology & Carcinogenesis
  • Odds Ratio
  • Neoplasm Staging
  • Neoplasm Recurrence, Local
 

Citation

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Meyerhardt, J. A., Sato, K., Niedzwiecki, D., Ye, C., Saltz, L. B., Mayer, R. J., … Fuchs, C. S. (2012). Dietary glycemic load and cancer recurrence and survival in patients with stage III colon cancer: findings from CALGB 89803. J Natl Cancer Inst, 104(22), 1702–1711. https://doi.org/10.1093/jnci/djs399
Meyerhardt, Jeffrey A., Kaori Sato, Donna Niedzwiecki, Cynthia Ye, Leonard B. Saltz, Robert J. Mayer, Rex B. Mowat, et al. “Dietary glycemic load and cancer recurrence and survival in patients with stage III colon cancer: findings from CALGB 89803.J Natl Cancer Inst 104, no. 22 (November 21, 2012): 1702–11. https://doi.org/10.1093/jnci/djs399.
Meyerhardt JA, Sato K, Niedzwiecki D, Ye C, Saltz LB, Mayer RJ, et al. Dietary glycemic load and cancer recurrence and survival in patients with stage III colon cancer: findings from CALGB 89803. J Natl Cancer Inst. 2012 Nov 21;104(22):1702–11.
Meyerhardt, Jeffrey A., et al. “Dietary glycemic load and cancer recurrence and survival in patients with stage III colon cancer: findings from CALGB 89803.J Natl Cancer Inst, vol. 104, no. 22, Nov. 2012, pp. 1702–11. Pubmed, doi:10.1093/jnci/djs399.
Meyerhardt JA, Sato K, Niedzwiecki D, Ye C, Saltz LB, Mayer RJ, Mowat RB, Whittom R, Hantel A, Benson A, Wigler DS, Venook A, Fuchs CS. Dietary glycemic load and cancer recurrence and survival in patients with stage III colon cancer: findings from CALGB 89803. J Natl Cancer Inst. 2012 Nov 21;104(22):1702–1711.
Journal cover image

Published In

J Natl Cancer Inst

DOI

EISSN

1460-2105

Publication Date

November 21, 2012

Volume

104

Issue

22

Start / End Page

1702 / 1711

Location

United States

Related Subject Headings

  • United States
  • Survival Analysis
  • Risk Factors
  • Randomized Controlled Trials as Topic
  • Prospective Studies
  • Proportional Hazards Models
  • Oncology & Carcinogenesis
  • Odds Ratio
  • Neoplasm Staging
  • Neoplasm Recurrence, Local