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Worse blood pressure control in patients with cerebrovascular or peripheral arterial disease compared with coronary artery disease.

Publication ,  Journal Article
Mechtouff, L; Touzé, E; Steg, PG; Ohman, EM; Goto, S; Hirsch, AT; Röther, J; Aichner, FT; Weimar, C; Bhatt, DL; Alberts, MJ; Mas, J-L ...
Published in: J Intern Med
June 2010

OBJECTIVES: Poor blood pressure (BP) control is common amongst patients with symptomatic atherothrombotic disease. It is unclear whether BP control and management differ across atherothrombotic disease subtypes. METHODS: We analysed the baseline data of 44,984 patients with documented coronary artery disease (CAD) only (n = 30,414), cerebrovascular disease (CVD) only (n = 11,359) and peripheral arterial disease (PAD) only (n = 3211) from the international REduction of Atherothrombosis for Continued Health Registry and investigated the impact of atherothrombotic disease subtype on BP control and use of antihypertensive drugs. RESULTS: The proportion of patients with BP controlled (<140/90 mmHg) was higher in CAD (58.1%) than in CVD (44.8%) or PAD (38.9%) patients (P < 0.001). Amongst patients with treated hypertension, CAD patients were more likely to have BP controlled than were CVD patients [odds ratio (OR) = 1.67; 95% confidence interval (CI) = 1.59-1.75] or PAD (OR = 2.30; 95% CI = 2.10-2.52). These differences were smaller in women than in men and decreased with age. Amongst treated patients, CAD patients were more likely to receive > or =3-drug combination therapies than were CVD (OR = 1.73; 95% CI = 1.64-1.83) or PAD (OR = 1.64; 95% CI = 1.49-1.80) patients. Adjustment for age, gender, waist obesity, diabetes, education level and world region did not alter the results. CONCLUSIONS: Coronary artery disease patients are more likely than CVD or PAD patients to have BP controlled and to receive antihypertensive drugs, particularly combination therapies. Promotion of more effective BP control through combination antihypertensive therapies could improve secondary prevention and therefore prevent complications in CVD and PAD patients.

Duke Scholars

Published In

J Intern Med

DOI

EISSN

1365-2796

Publication Date

June 2010

Volume

267

Issue

6

Start / End Page

621 / 633

Location

England

Related Subject Headings

  • Sex Factors
  • Peripheral Vascular Diseases
  • Middle Aged
  • Male
  • Hypertension
  • Humans
  • Female
  • Coronary Artery Disease
  • Cerebrovascular Disorders
  • Cardiovascular System & Hematology
 

Citation

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Mechtouff, L., Touzé, E., Steg, P. G., Ohman, E. M., Goto, S., Hirsch, A. T., … REACH Registry Investigators, . (2010). Worse blood pressure control in patients with cerebrovascular or peripheral arterial disease compared with coronary artery disease. J Intern Med, 267(6), 621–633. https://doi.org/10.1111/j.1365-2796.2009.02198.x
Mechtouff, L., E. Touzé, P. G. Steg, E. M. Ohman, S. Goto, A. T. Hirsch, J. Röther, et al. “Worse blood pressure control in patients with cerebrovascular or peripheral arterial disease compared with coronary artery disease.J Intern Med 267, no. 6 (June 2010): 621–33. https://doi.org/10.1111/j.1365-2796.2009.02198.x.
Mechtouff L, Touzé E, Steg PG, Ohman EM, Goto S, Hirsch AT, et al. Worse blood pressure control in patients with cerebrovascular or peripheral arterial disease compared with coronary artery disease. J Intern Med. 2010 Jun;267(6):621–33.
Mechtouff, L., et al. “Worse blood pressure control in patients with cerebrovascular or peripheral arterial disease compared with coronary artery disease.J Intern Med, vol. 267, no. 6, June 2010, pp. 621–33. Pubmed, doi:10.1111/j.1365-2796.2009.02198.x.
Mechtouff L, Touzé E, Steg PG, Ohman EM, Goto S, Hirsch AT, Röther J, Aichner FT, Weimar C, Bhatt DL, Alberts MJ, Mas J-L, REACH Registry Investigators. Worse blood pressure control in patients with cerebrovascular or peripheral arterial disease compared with coronary artery disease. J Intern Med. 2010 Jun;267(6):621–633.
Journal cover image

Published In

J Intern Med

DOI

EISSN

1365-2796

Publication Date

June 2010

Volume

267

Issue

6

Start / End Page

621 / 633

Location

England

Related Subject Headings

  • Sex Factors
  • Peripheral Vascular Diseases
  • Middle Aged
  • Male
  • Hypertension
  • Humans
  • Female
  • Coronary Artery Disease
  • Cerebrovascular Disorders
  • Cardiovascular System & Hematology