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Relation of impaired Thrombolysis In Myocardial Infarction myocardial perfusion grades to residual thrombus following the restoration of epicardial patency in ST-elevation myocardial infarction.

Publication ,  Journal Article
Kirtane, AJ; Weisbord, A; Karmpaliotis, D; Murphy, SA; Giugliano, RP; Cannon, CP; Antman, EM; Ohman, EM; Roe, MT; Braunwald, E; Gibson, CM ...
Published in: Am J Cardiol
January 15, 2005

Clinical and angiographic data were analyzed from 929 patients who had ST-elevation myocardial infarction and open epicardial arteries after fibrinolytic therapy. Residual angiographically evident thrombus was associated with more frequent Thrombolysis In Myocardial Infarction (TIMI) grade 2 flow (33.6% vs 26.8%, p = 0.03), higher corrected TIMI frame counts (34 vs 31 frames, p = 0.0003), and lower TIMI myocardial perfusion grades (43.0% vs 32.0% TIMI myocardial perfusion grades 0/1, p = 0.001) among all patients and among patients who had TIMI grade 3 flow (33.5% vs 26.0% TIMI myocardial perfusion grades 0/1, p = 0.043). In multivariate analyses, angiographically evident thrombus was associated with higher corrected TIMI frame counts and worsened myocardial perfusion independent of clinical and angiographic covariates, including TIMI grade 3 flow.

Duke Scholars

Published In

Am J Cardiol

DOI

ISSN

0002-9149

Publication Date

January 15, 2005

Volume

95

Issue

2

Start / End Page

224 / 227

Location

United States

Related Subject Headings

  • Tissue Plasminogen Activator
  • Thrombolytic Therapy
  • Myocardial Infarction
  • Infusions, Intravenous
  • Humans
  • Coronary Circulation
  • Coronary Angiography
  • Cardiovascular System & Hematology
  • Blood Flow Velocity
  • 3201 Cardiovascular medicine and haematology
 

Citation

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MLA
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Kirtane, A. J., Weisbord, A., Karmpaliotis, D., Murphy, S. A., Giugliano, R. P., Cannon, C. P., … TIMI Study Group, . (2005). Relation of impaired Thrombolysis In Myocardial Infarction myocardial perfusion grades to residual thrombus following the restoration of epicardial patency in ST-elevation myocardial infarction. Am J Cardiol, 95(2), 224–227. https://doi.org/10.1016/j.amjcard.2004.09.007
Kirtane, Ajay J., Aaron Weisbord, Dimitrios Karmpaliotis, Sabina A. Murphy, Robert P. Giugliano, Christopher P. Cannon, Elliott M. Antman, et al. “Relation of impaired Thrombolysis In Myocardial Infarction myocardial perfusion grades to residual thrombus following the restoration of epicardial patency in ST-elevation myocardial infarction.Am J Cardiol 95, no. 2 (January 15, 2005): 224–27. https://doi.org/10.1016/j.amjcard.2004.09.007.
Kirtane AJ, Weisbord A, Karmpaliotis D, Murphy SA, Giugliano RP, Cannon CP, Antman EM, Ohman EM, Roe MT, Braunwald E, Gibson CM, TIMI Study Group. Relation of impaired Thrombolysis In Myocardial Infarction myocardial perfusion grades to residual thrombus following the restoration of epicardial patency in ST-elevation myocardial infarction. Am J Cardiol. 2005 Jan 15;95(2):224–227.
Journal cover image

Published In

Am J Cardiol

DOI

ISSN

0002-9149

Publication Date

January 15, 2005

Volume

95

Issue

2

Start / End Page

224 / 227

Location

United States

Related Subject Headings

  • Tissue Plasminogen Activator
  • Thrombolytic Therapy
  • Myocardial Infarction
  • Infusions, Intravenous
  • Humans
  • Coronary Circulation
  • Coronary Angiography
  • Cardiovascular System & Hematology
  • Blood Flow Velocity
  • 3201 Cardiovascular medicine and haematology