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Effectiveness of various barrier preparations in preventing and/or ameliorating experimentally produced Toxicodendron dermatitis.

Publication ,  Journal Article
Grevelink, SA; Murrell, DF; Olsen, EA
Published in: J Am Acad Dermatol
August 1992

BACKGROUND: Despite extensive research on hyposensitization and prior application of topical barrier preparations, efforts to prevent Toxicodendron dermatitis have been only minimally successful. OBJECTIVE: Seven different barrier creams were evaluated for topical protection against experimentally produced Toxicodendron dermatitis in a randomized, double-blind study. METHODS: Twenty patients had the seven barrier creams randomly applied to eight test sites (one untreated area as control) on each forearm before application of the Toxicodendron extract. Development of Toxicodendron dermatitis was followed for 8 days, with measurements of erythema, induration, vesiculation, and global severity taken at each site on days 1, 2, 3, 4, and 7 after Toxicodendron application. RESULTS: The barrier creams Stokogard, Hollister Moisture Barrier, and Hydropel significantly reduced the erythema, induration, and global severity of Toxicodendron dermatitis and did not differ from each other. The percent reductions in global dermatitis severity per day of assessment for the seven barriers in order of effectiveness were as follows: Stokogard, 59%; Hollister Moisture Barrier, 52%; Hydropel, 48%; Ivy Shield, 22%; Shield Skin, 13%; Dermofilm, 13%; and Uniderm, -9%. During the 8-day period, a significantly greater number of test sites pretreated with Stokogard, Hollister Moisture Barrier, and Hydropel were free of dermatitis compared with control sites and sites treated with the other four barriers. CONCLUSION: The results indicate that Stokogard, Hollister Moisture Barrier, and Hydropel are effective in the prevention of Toxicodendron dermatitis.

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Published In

J Am Acad Dermatol

DOI

ISSN

0190-9622

Publication Date

August 1992

Volume

27

Issue

2 Pt 1

Start / End Page

182 / 188

Location

United States

Related Subject Headings

  • Patch Tests
  • Middle Aged
  • Male
  • Humans
  • Female
  • Emollients
  • Double-Blind Method
  • Dermatology & Venereal Diseases
  • Dermatitis, Toxicodendron
  • Adult
 

Citation

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Grevelink, S. A., Murrell, D. F., & Olsen, E. A. (1992). Effectiveness of various barrier preparations in preventing and/or ameliorating experimentally produced Toxicodendron dermatitis. J Am Acad Dermatol, 27(2 Pt 1), 182–188. https://doi.org/10.1016/0190-9622(92)70167-e
Grevelink, S. A., D. F. Murrell, and E. A. Olsen. “Effectiveness of various barrier preparations in preventing and/or ameliorating experimentally produced Toxicodendron dermatitis.J Am Acad Dermatol 27, no. 2 Pt 1 (August 1992): 182–88. https://doi.org/10.1016/0190-9622(92)70167-e.
Grevelink, S. A., et al. “Effectiveness of various barrier preparations in preventing and/or ameliorating experimentally produced Toxicodendron dermatitis.J Am Acad Dermatol, vol. 27, no. 2 Pt 1, Aug. 1992, pp. 182–88. Pubmed, doi:10.1016/0190-9622(92)70167-e.
Grevelink SA, Murrell DF, Olsen EA. Effectiveness of various barrier preparations in preventing and/or ameliorating experimentally produced Toxicodendron dermatitis. J Am Acad Dermatol. 1992 Aug;27(2 Pt 1):182–188.
Journal cover image

Published In

J Am Acad Dermatol

DOI

ISSN

0190-9622

Publication Date

August 1992

Volume

27

Issue

2 Pt 1

Start / End Page

182 / 188

Location

United States

Related Subject Headings

  • Patch Tests
  • Middle Aged
  • Male
  • Humans
  • Female
  • Emollients
  • Double-Blind Method
  • Dermatology & Venereal Diseases
  • Dermatitis, Toxicodendron
  • Adult