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Comparison of oral fluconazole and topical clotrimazole in the treatment of fungal infections of the skin: European and American experience

Publication ,  Journal Article
De Bersaques, J; Bjerke, JR; Borelli, S; Brown, AC; Cottenot, F; Daniel, F; Dupont, B; Gschnait, F; Heenen, M; Jegasothy, BV; Kramer, M ...
Published in: International Journal of Dermatology
January 1, 1992

An open, comparative, multicenter study conducted in Europe and the United States evaluated the efficacy and safety of oral fluconazole and topical clotrimazole in fungal infections of the skin. Patients were randomized to receive fluconazole, 50 mg per day, or clotrimazole 1% topical cream, twice daily, for up to 6 weeks. Clinical response at the end of therapy was similar in both treatment groups. In the European trial, 96% and 95% of evaluable sites were cured or improved following treatment with fluconazole or clotrimazole, respectively. Results of the US trial revealed response rates of 94% and 89%, respectively. Improvement was maintained at follow-up 2 to 4 weeks after the end of treatment. Mycologic cure at the end of treatment in the European trial, which was observed in 85% and 86% of fluconazole-treated and clotrimazole-treated sites, respectively, was maintained at follow-up. A similar trend was seen in the US trial with cure rates of 66% and 72%, respectively. Both drugs were well tolerated. Whereas side effects in the fluconazole group consisted mainly of headaches and gastrointestinal disorders, the clotrimazole group exhibited local hypersensitivity reactions. Laboratory test abnormalities occurred with equal frequency within both treatment groups, with no evidence of clinically significant adverse changes. The results of these studies confirm that fluconazole is as efficacious as the established agent clotrimazole in the treatment of patients with fungal infections of the skin.

Duke Scholars

Published In

International Journal of Dermatology

ISSN

0011-9059

Publication Date

January 1, 1992

Volume

31

Issue

SUPPL. 2

Start / End Page

21 / 26

Related Subject Headings

  • Dermatology & Venereal Diseases
  • 3202 Clinical sciences
  • 1117 Public Health and Health Services
  • 1103 Clinical Sciences
 

Citation

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De Bersaques, J., Bjerke, J. R., Borelli, S., Brown, A. C., Cottenot, F., Daniel, F., … Shubert, B. (1992). Comparison of oral fluconazole and topical clotrimazole in the treatment of fungal infections of the skin: European and American experience. International Journal of Dermatology, 31(SUPPL. 2), 21–26.
De Bersaques, J., J. R. Bjerke, S. Borelli, A. C. Brown, F. Cottenot, F. Daniel, B. Dupont, et al. “Comparison of oral fluconazole and topical clotrimazole in the treatment of fungal infections of the skin: European and American experience.” International Journal of Dermatology 31, no. SUPPL. 2 (January 1, 1992): 21–26.
De Bersaques J, Bjerke JR, Borelli S, Brown AC, Cottenot F, Daniel F, et al. Comparison of oral fluconazole and topical clotrimazole in the treatment of fungal infections of the skin: European and American experience. International Journal of Dermatology. 1992 Jan 1;31(SUPPL. 2):21–6.
De Bersaques, J., et al. “Comparison of oral fluconazole and topical clotrimazole in the treatment of fungal infections of the skin: European and American experience.” International Journal of Dermatology, vol. 31, no. SUPPL. 2, Jan. 1992, pp. 21–26.
De Bersaques J, Bjerke JR, Borelli S, Brown AC, Cottenot F, Daniel F, Dupont B, Gschnait F, Heenen M, Jegasothy BV, Kramer M, Lapiere C, Neldner KH, Olsen EA, Parish LC, Privat Y, Savin RC, Schnabel P, Shubert B. Comparison of oral fluconazole and topical clotrimazole in the treatment of fungal infections of the skin: European and American experience. International Journal of Dermatology. 1992 Jan 1;31(SUPPL. 2):21–26.
Journal cover image

Published In

International Journal of Dermatology

ISSN

0011-9059

Publication Date

January 1, 1992

Volume

31

Issue

SUPPL. 2

Start / End Page

21 / 26

Related Subject Headings

  • Dermatology & Venereal Diseases
  • 3202 Clinical sciences
  • 1117 Public Health and Health Services
  • 1103 Clinical Sciences