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A double-blind, vehicle-controlled study evaluating masoprocol cream in the treatment of actinic keratoses on the head and neck.

Publication ,  Journal Article
Olsen, EA; Abernethy, ML; Kulp-Shorten, C; Callen, JP; Glazer, SD; Huntley, A; McCray, M; Monroe, AB; Tschen, E; Wolf, JE
Published in: J Am Acad Dermatol
May 1991

This double-blind, vehicle-controlled, multicenter study evaluated the efficacy and safety of a new topical antineoplastic agent, masoprocol, in the treatment of actinic keratoses of the head and neck. Of the 113 patients who applied topical masoprocol twice a day for 14 to 28 days, there was a mean decrease in actinic keratoses from 15.0 to 5.4 and a median percent reduction from baseline actinic keratosis count of 71.4% at the 1-month follow-up visit. Comparable numbers for the vehicle-treated group were 13.4 to 11.1 actinic keratoses and 4.3% median percent reduction. Irritation, as manifested by erythema or flaking, occurred in 61.5% of topical masoprocol-treated patients versus 26.7% of those treated with vehicle and did not correlate with clinical response. Topical masoprocol appears to be useful in the treatment of actinic keratoses.

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Published In

J Am Acad Dermatol

DOI

ISSN

0190-9622

Publication Date

May 1991

Volume

24

Issue

5 Pt 1

Start / End Page

738 / 743

Location

United States

Related Subject Headings

  • Ointments
  • Middle Aged
  • Masoprocol
  • Male
  • Keratosis
  • Humans
  • Head
  • Female
  • Facial Dermatoses
  • Double-Blind Method
 

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Olsen, E. A., Abernethy, M. L., Kulp-Shorten, C., Callen, J. P., Glazer, S. D., Huntley, A., … Wolf, J. E. (1991). A double-blind, vehicle-controlled study evaluating masoprocol cream in the treatment of actinic keratoses on the head and neck. J Am Acad Dermatol, 24(5 Pt 1), 738–743. https://doi.org/10.1016/0190-9622(91)70113-g
Olsen, E. A., M. L. Abernethy, C. Kulp-Shorten, J. P. Callen, S. D. Glazer, A. Huntley, M. McCray, A. B. Monroe, E. Tschen, and J. E. Wolf. “A double-blind, vehicle-controlled study evaluating masoprocol cream in the treatment of actinic keratoses on the head and neck.J Am Acad Dermatol 24, no. 5 Pt 1 (May 1991): 738–43. https://doi.org/10.1016/0190-9622(91)70113-g.
Olsen EA, Abernethy ML, Kulp-Shorten C, Callen JP, Glazer SD, Huntley A, et al. A double-blind, vehicle-controlled study evaluating masoprocol cream in the treatment of actinic keratoses on the head and neck. J Am Acad Dermatol. 1991 May;24(5 Pt 1):738–43.
Olsen, E. A., et al. “A double-blind, vehicle-controlled study evaluating masoprocol cream in the treatment of actinic keratoses on the head and neck.J Am Acad Dermatol, vol. 24, no. 5 Pt 1, May 1991, pp. 738–43. Pubmed, doi:10.1016/0190-9622(91)70113-g.
Olsen EA, Abernethy ML, Kulp-Shorten C, Callen JP, Glazer SD, Huntley A, McCray M, Monroe AB, Tschen E, Wolf JE. A double-blind, vehicle-controlled study evaluating masoprocol cream in the treatment of actinic keratoses on the head and neck. J Am Acad Dermatol. 1991 May;24(5 Pt 1):738–743.
Journal cover image

Published In

J Am Acad Dermatol

DOI

ISSN

0190-9622

Publication Date

May 1991

Volume

24

Issue

5 Pt 1

Start / End Page

738 / 743

Location

United States

Related Subject Headings

  • Ointments
  • Middle Aged
  • Masoprocol
  • Male
  • Keratosis
  • Humans
  • Head
  • Female
  • Facial Dermatoses
  • Double-Blind Method