Chronic hypergastrinemia: causes and consequences.
Publication
, Journal Article
Orlando, LA; Lenard, L; Orlando, RC
Published in: Dig Dis Sci
October 2007
The hormone gastrin plays 2 important roles in gastrointestinal physiology--1 as a major factor in meal-stimulated gastric acid secretion and the other as a trophic hormone for epithelial and enterochromaffin cells. These roles are exaggerated to the point of pathology under conditions of chronic hypergastrinemia as exemplified by the Zollinger-Ellison syndrome and pernicious anemia. More recently, the concern about the potential risk of chronic hypergastrinemia has risen because of the widespread use of proton pump inhibitors for maintenance therapy in reflux esophagitis. For this reason, we present a concise overview of the origin, causes, and potential risks of chronic hypergastrinemia.
Duke Scholars
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Published In
Dig Dis Sci
DOI
ISSN
0163-2116
Publication Date
October 2007
Volume
52
Issue
10
Start / End Page
2482 / 2489
Location
United States
Related Subject Headings
- Zollinger-Ellison Syndrome
- Risk Factors
- Proton Pump Inhibitors
- Peptic Ulcer
- Humans
- Gastroenterology & Hepatology
- Gastritis, Atrophic
- Gastrins
- Gastrinoma
- Gastric Acid
Citation
APA
Chicago
ICMJE
MLA
NLM
Orlando, L. A., Lenard, L., & Orlando, R. C. (2007). Chronic hypergastrinemia: causes and consequences. Dig Dis Sci, 52(10), 2482–2489. https://doi.org/10.1007/s10620-006-9419-3
Orlando, Lori A., Lane Lenard, and Roy C. Orlando. “Chronic hypergastrinemia: causes and consequences.” Dig Dis Sci 52, no. 10 (October 2007): 2482–89. https://doi.org/10.1007/s10620-006-9419-3.
Orlando LA, Lenard L, Orlando RC. Chronic hypergastrinemia: causes and consequences. Dig Dis Sci. 2007 Oct;52(10):2482–9.
Orlando, Lori A., et al. “Chronic hypergastrinemia: causes and consequences.” Dig Dis Sci, vol. 52, no. 10, Oct. 2007, pp. 2482–89. Pubmed, doi:10.1007/s10620-006-9419-3.
Orlando LA, Lenard L, Orlando RC. Chronic hypergastrinemia: causes and consequences. Dig Dis Sci. 2007 Oct;52(10):2482–2489.
Published In
Dig Dis Sci
DOI
ISSN
0163-2116
Publication Date
October 2007
Volume
52
Issue
10
Start / End Page
2482 / 2489
Location
United States
Related Subject Headings
- Zollinger-Ellison Syndrome
- Risk Factors
- Proton Pump Inhibitors
- Peptic Ulcer
- Humans
- Gastroenterology & Hepatology
- Gastritis, Atrophic
- Gastrins
- Gastrinoma
- Gastric Acid