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Prevention of VTE in orthopedic surgery patients: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines.

Publication ,  Journal Article
Falck-Ytter, Y; Francis, CW; Johanson, NA; Curley, C; Dahl, OE; Schulman, S; Ortel, TL; Pauker, SG; Colwell, CW
Published in: Chest
February 2012

BACKGROUND: VTE is a serious, but decreasing complication following major orthopedic surgery. This guideline focuses on optimal prophylaxis to reduce postoperative pulmonary embolism and DVT. METHODS: The methods of this guideline follow those described in Methodology for the Development of Antithrombotic Therapy and Prevention of Thrombosis Guidelines: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines in this supplement. RESULTS: In patients undergoing major orthopedic surgery, we recommend the use of one of the following rather than no antithrombotic prophylaxis: low-molecular-weight heparin; fondaparinux; dabigatran, apixaban, rivaroxaban (total hip arthroplasty or total knee arthroplasty but not hip fracture surgery); low-dose unfractionated heparin; adjusted-dose vitamin K antagonist; aspirin (all Grade 1B); or an intermittent pneumatic compression device (IPCD) (Grade 1C) for a minimum of 10 to 14 days. We suggest the use of low-molecular-weight heparin in preference to the other agents we have recommended as alternatives (Grade 2C/2B), and in patients receiving pharmacologic prophylaxis, we suggest adding an IPCD during the hospital stay (Grade 2C). We suggest extending thromboprophylaxis for up to 35 days (Grade 2B). In patients at increased bleeding risk, we suggest an IPCD or no prophylaxis (Grade 2C). In patients who decline injections, we recommend using apixaban or dabigatran (all Grade 1B). We suggest against using inferior vena cava filter placement for primary prevention in patients with contraindications to both pharmacologic and mechanical thromboprophylaxis (Grade 2C). We recommend against Doppler (or duplex) ultrasonography screening before hospital discharge (Grade 1B). For patients with isolated lower-extremity injuries requiring leg immobilization, we suggest no thromboprophylaxis (Grade 2B). For patients undergoing knee arthroscopy without a history of VTE, we suggest no thromboprophylaxis (Grade 2B). CONCLUSIONS: Optimal strategies for thromboprophylaxis after major orthopedic surgery include pharmacologic and mechanical approaches.

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Published In

Chest

DOI

EISSN

1931-3543

Publication Date

February 2012

Volume

141

Issue

2 Suppl

Start / End Page

e278S / e325S

Location

United States

Related Subject Headings

  • Venous Thromboembolism
  • Societies, Medical
  • Risk Factors
  • Respiratory System
  • Pulmonary Embolism
  • Postoperative Complications
  • Orthopedic Procedures
  • Intermittent Pneumatic Compression Devices
  • Humans
  • Hemorrhage
 

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Falck-Ytter, Y., Francis, C. W., Johanson, N. A., Curley, C., Dahl, O. E., Schulman, S., … Colwell, C. W. (2012). Prevention of VTE in orthopedic surgery patients: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest, 141(2 Suppl), e278S-e325S. https://doi.org/10.1378/chest.11-2404
Falck-Ytter, Yngve, Charles W. Francis, Norman A. Johanson, Catherine Curley, Ola E. Dahl, Sam Schulman, Thomas L. Ortel, Stephen G. Pauker, and Clifford W. Colwell. “Prevention of VTE in orthopedic surgery patients: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines.Chest 141, no. 2 Suppl (February 2012): e278S-e325S. https://doi.org/10.1378/chest.11-2404.
Falck-Ytter Y, Francis CW, Johanson NA, Curley C, Dahl OE, Schulman S, Ortel TL, Pauker SG, Colwell CW. Prevention of VTE in orthopedic surgery patients: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest. 2012 Feb;141(2 Suppl):e278S-e325S.

Published In

Chest

DOI

EISSN

1931-3543

Publication Date

February 2012

Volume

141

Issue

2 Suppl

Start / End Page

e278S / e325S

Location

United States

Related Subject Headings

  • Venous Thromboembolism
  • Societies, Medical
  • Risk Factors
  • Respiratory System
  • Pulmonary Embolism
  • Postoperative Complications
  • Orthopedic Procedures
  • Intermittent Pneumatic Compression Devices
  • Humans
  • Hemorrhage