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Histologic observations and P-glycoprotein expression in gastric and esophageal adenocarcinomas treated with preoperative chemotherapy.

Publication ,  Journal Article
Robey-Cafferty, SS; Ajani, JA; Ota, DM; Roth, JA; Bruner, JM
Published in: Arch Pathol Lab Med
August 1991

To describe histologic changes associated with chemotherapy response, we reviewed biopsy and resection specimens from 52 patients with locally advanced esophageal or gastric adenocarcinoma who were treated with preoperative chemotherapy, followed by resection. P-Glycoprotein expression in the adenocarcinomas was also determined with the use of antibody C219. Significant changes in morphologic appearance of the tumor between prechemotherapy and postchemotherapy samples was noted in 17 tumors (32.7%). The most frequent changes observed in these 17 tumors were a decrease in tumor cellularity and an increase in dense fibrosis in comparison with the prechemotherapy specimen. In signet-ring cell carcinomas, the intracytoplasmic mucin vacuoles were often smaller after chemotherapy, making tumor cells more difficult to identify. Another finding observed in tumors that showed histologic alteration after chemotherapy was the formation of large mucin pools that contained lymphocytes and macrophages. The remaining 35 tumors showed similar histologic features in prechemotherapy and postchemotherapy specimens. P-Glycoprotein was identified in 15 (29.4%) of 51 specimens after chemotherapy. P-Glycoprotein content of the residual tumors did not correlate with stage, degree of differentiation, or clinically determined chemotherapy response. We concluded that chemotherapy-induced changes in morphology were frequent in patients with upper gastrointestinal tract adenocarcinomas treated with preoperative chemotherapy. These changes should be recognized as they may cause difficulties in both gross and histologic evaluation of the extent of tumor in postchemotherapy resection specimens. The response of adenocarcinomas to this chemotherapy protocol does not appear to be linked to P-glycoprotein expression.

Duke Scholars

Published In

Arch Pathol Lab Med

ISSN

0003-9985

Publication Date

August 1991

Volume

115

Issue

8

Start / End Page

807 / 812

Location

United States

Related Subject Headings

  • Stomach Neoplasms
  • Staining and Labeling
  • Preoperative Care
  • Pathology
  • Middle Aged
  • Membrane Glycoproteins
  • Immunoenzyme Techniques
  • Humans
  • Esophageal Neoplasms
  • Antineoplastic Agents
 

Citation

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MLA
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Robey-Cafferty, S. S., Ajani, J. A., Ota, D. M., Roth, J. A., & Bruner, J. M. (1991). Histologic observations and P-glycoprotein expression in gastric and esophageal adenocarcinomas treated with preoperative chemotherapy. Arch Pathol Lab Med, 115(8), 807–812.
Robey-Cafferty, S. S., J. A. Ajani, D. M. Ota, J. A. Roth, and J. M. Bruner. “Histologic observations and P-glycoprotein expression in gastric and esophageal adenocarcinomas treated with preoperative chemotherapy.Arch Pathol Lab Med 115, no. 8 (August 1991): 807–12.
Robey-Cafferty SS, Ajani JA, Ota DM, Roth JA, Bruner JM. Histologic observations and P-glycoprotein expression in gastric and esophageal adenocarcinomas treated with preoperative chemotherapy. Arch Pathol Lab Med. 1991 Aug;115(8):807–12.
Robey-Cafferty, S. S., et al. “Histologic observations and P-glycoprotein expression in gastric and esophageal adenocarcinomas treated with preoperative chemotherapy.Arch Pathol Lab Med, vol. 115, no. 8, Aug. 1991, pp. 807–12.
Robey-Cafferty SS, Ajani JA, Ota DM, Roth JA, Bruner JM. Histologic observations and P-glycoprotein expression in gastric and esophageal adenocarcinomas treated with preoperative chemotherapy. Arch Pathol Lab Med. 1991 Aug;115(8):807–812.

Published In

Arch Pathol Lab Med

ISSN

0003-9985

Publication Date

August 1991

Volume

115

Issue

8

Start / End Page

807 / 812

Location

United States

Related Subject Headings

  • Stomach Neoplasms
  • Staining and Labeling
  • Preoperative Care
  • Pathology
  • Middle Aged
  • Membrane Glycoproteins
  • Immunoenzyme Techniques
  • Humans
  • Esophageal Neoplasms
  • Antineoplastic Agents