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In vitro effects of fluoride and bromide on pseudocholinesterase and acetylcholinesterase activities.

Publication ,  Journal Article
Kambam, JR; Parris, WC; Naukam, RJ; Franks, JJ; Sastry, BV
Published in: Can J Anaesth
November 1990

The in vitro effects of two metabolites of inhalational anaesthetics, fluoride and bromide, on pseudocholinesterase (PCHE) and acetylcholinesterase (ACHE) activities in the blood samples of seven healthy patients were studied. The PCHE and ACHE activities were determined by kinetic spectrophotometric methods. Fluoride at the levels achieved with clinical concentrations of enflurane and sevoflurane (25-75 microM.L-1) inhibited PCHE activity by 28-65 per cent (P less than 0.01) and ACHE activity by less than five per cent (P greater than 0.05). Bromide at the levels achieved with clinical concentrations of inhalational anaesthetics had no significant effect on either PCHE or ACHE activity. We recommend caution when succinylcholine and/or ester type local anaesthetics are used in the immediate postoperative period following enflurane or sevoflurane anaesthesia. We also recommend that blood drawing for PCHE activity be delayed at least until 24 hr following enflurane or sevoflurane anaesthesia.

Duke Scholars

Published In

Can J Anaesth

DOI

ISSN

0832-610X

Publication Date

November 1990

Volume

37

Issue

8

Start / End Page

916 / 919

Location

United States

Related Subject Headings

  • Spectrophotometry
  • Regression Analysis
  • Middle Aged
  • Male
  • Humans
  • Fluorides
  • Female
  • Calorimetry
  • Butyrylcholinesterase
  • Bromides
 

Citation

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Kambam, J. R., Parris, W. C., Naukam, R. J., Franks, J. J., & Sastry, B. V. (1990). In vitro effects of fluoride and bromide on pseudocholinesterase and acetylcholinesterase activities. Can J Anaesth, 37(8), 916–919. https://doi.org/10.1007/BF03006636
Kambam, J. R., W. C. Parris, R. J. Naukam, J. J. Franks, and B. V. Sastry. “In vitro effects of fluoride and bromide on pseudocholinesterase and acetylcholinesterase activities.Can J Anaesth 37, no. 8 (November 1990): 916–19. https://doi.org/10.1007/BF03006636.
Kambam JR, Parris WC, Naukam RJ, Franks JJ, Sastry BV. In vitro effects of fluoride and bromide on pseudocholinesterase and acetylcholinesterase activities. Can J Anaesth. 1990 Nov;37(8):916–9.
Kambam, J. R., et al. “In vitro effects of fluoride and bromide on pseudocholinesterase and acetylcholinesterase activities.Can J Anaesth, vol. 37, no. 8, Nov. 1990, pp. 916–19. Pubmed, doi:10.1007/BF03006636.
Kambam JR, Parris WC, Naukam RJ, Franks JJ, Sastry BV. In vitro effects of fluoride and bromide on pseudocholinesterase and acetylcholinesterase activities. Can J Anaesth. 1990 Nov;37(8):916–919.
Journal cover image

Published In

Can J Anaesth

DOI

ISSN

0832-610X

Publication Date

November 1990

Volume

37

Issue

8

Start / End Page

916 / 919

Location

United States

Related Subject Headings

  • Spectrophotometry
  • Regression Analysis
  • Middle Aged
  • Male
  • Humans
  • Fluorides
  • Female
  • Calorimetry
  • Butyrylcholinesterase
  • Bromides