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Biomarkers of liver fibrosis: what lies beneath the receiver operating characteristic curve?

Publication ,  Journal Article
Guha, IN; Myers, RP; Patel, K; Talwalkar, JA
Published in: Hepatology
October 2011

Noninvasive biomarkers of liver fibrosis represent an intense area of research with the goals of improving patient care, disease stratification, and aiding the development of future antifibrotic therapies. Despite the rapid progress in recent years, there remain questions about how diagnostic studies are designed, statistical methods to account for spectrum bias, clinically relevant thresholds of fibrosis that should be delineated, how diagnostics can be improved, and strengthening the reference test to judge emerging biomarkers. This review discusses the current methods to address these issues and where further progress is needed.

Duke Scholars

Published In

Hepatology

DOI

EISSN

1527-3350

Publication Date

October 2011

Volume

54

Issue

4

Start / End Page

1454 / 1462

Location

United States

Related Subject Headings

  • United Kingdom
  • Severity of Illness Index
  • ROC Curve
  • Predictive Value of Tests
  • Male
  • Liver Cirrhosis
  • Humans
  • Gastroenterology & Hepatology
  • Female
  • Biomarkers
 

Citation

APA
Chicago
ICMJE
MLA
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Guha, I. N., Myers, R. P., Patel, K., & Talwalkar, J. A. (2011). Biomarkers of liver fibrosis: what lies beneath the receiver operating characteristic curve? Hepatology, 54(4), 1454–1462. https://doi.org/10.1002/hep.24515
Guha, Indra Neil, Robert P. Myers, Keyur Patel, and Jayant A. Talwalkar. “Biomarkers of liver fibrosis: what lies beneath the receiver operating characteristic curve?Hepatology 54, no. 4 (October 2011): 1454–62. https://doi.org/10.1002/hep.24515.
Guha IN, Myers RP, Patel K, Talwalkar JA. Biomarkers of liver fibrosis: what lies beneath the receiver operating characteristic curve? Hepatology. 2011 Oct;54(4):1454–62.
Guha, Indra Neil, et al. “Biomarkers of liver fibrosis: what lies beneath the receiver operating characteristic curve?Hepatology, vol. 54, no. 4, Oct. 2011, pp. 1454–62. Pubmed, doi:10.1002/hep.24515.
Guha IN, Myers RP, Patel K, Talwalkar JA. Biomarkers of liver fibrosis: what lies beneath the receiver operating characteristic curve? Hepatology. 2011 Oct;54(4):1454–1462.
Journal cover image

Published In

Hepatology

DOI

EISSN

1527-3350

Publication Date

October 2011

Volume

54

Issue

4

Start / End Page

1454 / 1462

Location

United States

Related Subject Headings

  • United Kingdom
  • Severity of Illness Index
  • ROC Curve
  • Predictive Value of Tests
  • Male
  • Liver Cirrhosis
  • Humans
  • Gastroenterology & Hepatology
  • Female
  • Biomarkers