Skip to main content
Journal cover image

Serum cholesterol and statin use predict virological response to peginterferon and ribavirin therapy.

Publication ,  Journal Article
Harrison, SA; Rossaro, L; Hu, K-Q; Patel, K; Tillmann, H; Dhaliwal, S; Torres, DM; Koury, K; Goteti, VS; Noviello, S; Brass, CA; Albrecht, JK ...
Published in: Hepatology
September 2010

UNLABELLED: Elevated low-density lipoprotein (LDL) levels and statin use have been associated with higher sustained virological response (SVR) rates in patients receiving chronic hepatitis C therapy. However, these relationships have not been well characterized in randomized controlled trials. Furthermore, little is known about the relationship between high-density lipoprotein (HDL) and virological response. To determine whether baseline LDL or HDL levels and statin use affect SVR rates, we retrospectively evaluated the IDEAL (Individualized Dosing Efficacy Versus Flat Dosing to Assess Optimal Pegylated Interferon Therapy) trial, in which 3070 treatment-naive, hepatitis C virus (HCV) genotype 1-infected patients were treated for up to 48 weeks in one of the following arms: (1) peginterferon (PEG-IFN) alfa-2b at 1.5 microg/kg/week with ribavirin (RBV) at 800 to 1400 mg/day, (2) PEG-IFN alfa-2b at 1.0 microg/kg/week with RBV at 800 to 1400 mg/day, or (3) PEG-IFN alfa-2a at 180 microg/week with RBV at 1000 to 1200 mg/day. Virological responses were assessed by pretreatment statin use and baseline elevated LDL levels (> or =130 mg/dL) or low HDL levels (<40 mg/dL for men and <50 mg/dL for women). In 1464 patients with baseline elevated LDL levels or low HDL levels, the SVR rate was significantly higher than that in patients with normal levels (44.9% versus 34.0%, P < 0.001). In 66 patients receiving a statin pretreatment, the SVR rate was higher than the rate of those not receiving it (53.0% versus 39.3%, P = 0.02). In a multivariate logistic regression analysis using the stepwise selection method with baseline characteristics, a high LDL level [odds ratio (OR) = 1.6, 95% confidence interval (CI) = 1.4-1.8, P < 0.001], a low HDL level (OR = 0.5, 95% CI = 0.3-0.8, P = 0.004), and statin use (OR = 2.0, 95% CI = 1.1-3.7, P = 0.02) were independently associated with SVR. CONCLUSION: Baseline elevated LDL levels or low HDL levels and preemptive statin usage were associated with higher SVR rates. Prospective studies may be considered to explore the biological impact of these factors on HCV RNA replication and treatment response.

Duke Scholars

Published In

Hepatology

DOI

EISSN

1527-3350

Publication Date

September 2010

Volume

52

Issue

3

Start / End Page

864 / 874

Location

United States

Related Subject Headings

  • Virus Replication
  • United States
  • Treatment Outcome
  • Ribavirin
  • Retrospective Studies
  • Regression Analysis
  • Recombinant Proteins
  • Predictive Value of Tests
  • Polyethylene Glycols
  • Middle Aged
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Harrison, S. A., Rossaro, L., Hu, K.-Q., Patel, K., Tillmann, H., Dhaliwal, S., … Sulkowski, M. S. (2010). Serum cholesterol and statin use predict virological response to peginterferon and ribavirin therapy. Hepatology, 52(3), 864–874. https://doi.org/10.1002/hep.23787
Harrison, Stephen A., Lorenzo Rossaro, Ke-Qin Hu, Keyur Patel, Hans Tillmann, Sandeep Dhaliwal, Dawn M. Torres, et al. “Serum cholesterol and statin use predict virological response to peginterferon and ribavirin therapy.Hepatology 52, no. 3 (September 2010): 864–74. https://doi.org/10.1002/hep.23787.
Harrison SA, Rossaro L, Hu K-Q, Patel K, Tillmann H, Dhaliwal S, et al. Serum cholesterol and statin use predict virological response to peginterferon and ribavirin therapy. Hepatology. 2010 Sep;52(3):864–74.
Harrison, Stephen A., et al. “Serum cholesterol and statin use predict virological response to peginterferon and ribavirin therapy.Hepatology, vol. 52, no. 3, Sept. 2010, pp. 864–74. Pubmed, doi:10.1002/hep.23787.
Harrison SA, Rossaro L, Hu K-Q, Patel K, Tillmann H, Dhaliwal S, Torres DM, Koury K, Goteti VS, Noviello S, Brass CA, Albrecht JK, McHutchison JG, Sulkowski MS. Serum cholesterol and statin use predict virological response to peginterferon and ribavirin therapy. Hepatology. 2010 Sep;52(3):864–874.
Journal cover image

Published In

Hepatology

DOI

EISSN

1527-3350

Publication Date

September 2010

Volume

52

Issue

3

Start / End Page

864 / 874

Location

United States

Related Subject Headings

  • Virus Replication
  • United States
  • Treatment Outcome
  • Ribavirin
  • Retrospective Studies
  • Regression Analysis
  • Recombinant Proteins
  • Predictive Value of Tests
  • Polyethylene Glycols
  • Middle Aged