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Antifibrotic therapies: will we ever get there?

Publication ,  Journal Article
Thompson, AJ; Patel, K
Published in: Curr Gastroenterol Rep
February 2010

Progressive hepatic fibrosis is the final common pathway for most chronic liver injuries, leading to cirrhosis with risk of liver failure and hepatocellular carcinoma. It is now recognized that fibrosis is a dynamic process, and may be reversible prior to the establishment of advanced architectural changes to the liver. The most effective antifibrotic strategy is to cure the underlying disease process before advanced fibrosis has developed. Unfortunately, this is often not possible, and specific antifibrotic therapies are needed. Advances in the understanding of the pathogenesis of liver fibrosis have identified several potential novel therapeutic targets, but unfortunately clinical development has been disappointing. One major limitation has been the often prolonged natural history of fibrosis compared to experimental models, and difficulties in accurate noninvasive fibrosis assessment, thus making clinical trial design difficult. In this review, we highlight the most promising current antifibrotic strategies.

Duke Scholars

Published In

Curr Gastroenterol Rep

DOI

EISSN

1534-312X

Publication Date

February 2010

Volume

12

Issue

1

Start / End Page

23 / 29

Location

United States

Related Subject Headings

  • PPAR gamma
  • Liver Cirrhosis
  • Interferon-gamma
  • Interferon-alpha
  • Humans
  • Gastroenterology & Hepatology
  • Caspase Inhibitors
  • Angiotensin II
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

Citation

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Thompson, A. J., & Patel, K. (2010). Antifibrotic therapies: will we ever get there? Curr Gastroenterol Rep, 12(1), 23–29. https://doi.org/10.1007/s11894-009-0080-9
Thompson, Alexander James, and Keyur Patel. “Antifibrotic therapies: will we ever get there?Curr Gastroenterol Rep 12, no. 1 (February 2010): 23–29. https://doi.org/10.1007/s11894-009-0080-9.
Thompson AJ, Patel K. Antifibrotic therapies: will we ever get there? Curr Gastroenterol Rep. 2010 Feb;12(1):23–9.
Thompson, Alexander James, and Keyur Patel. “Antifibrotic therapies: will we ever get there?Curr Gastroenterol Rep, vol. 12, no. 1, Feb. 2010, pp. 23–29. Pubmed, doi:10.1007/s11894-009-0080-9.
Thompson AJ, Patel K. Antifibrotic therapies: will we ever get there? Curr Gastroenterol Rep. 2010 Feb;12(1):23–29.
Journal cover image

Published In

Curr Gastroenterol Rep

DOI

EISSN

1534-312X

Publication Date

February 2010

Volume

12

Issue

1

Start / End Page

23 / 29

Location

United States

Related Subject Headings

  • PPAR gamma
  • Liver Cirrhosis
  • Interferon-gamma
  • Interferon-alpha
  • Humans
  • Gastroenterology & Hepatology
  • Caspase Inhibitors
  • Angiotensin II
  • 3202 Clinical sciences
  • 1103 Clinical Sciences