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Antisense inhibitors, ribozymes, and siRNAs.

Publication ,  Journal Article
Thompson, AJV; Patel, K
Published in: Clin Liver Dis
August 2009

The current standard of care for the treatment of hepatitis C virus infection, pegylated interferon-alpha and ribavirin, is costly, associated with significant side effects, and effective in only 50% of patients. There is therefore a need for the development of novel antiviral therapies. One such approach involves the application of gene silencing technologies, including antisense oligonucleotides, ribozymes, RNA interference, and aptamers. However, despite great scientific advances over the past decade, and promising in vitro data, several significant challenges continue to limit the translation of this technology to the clinical setting. This review provides a concise update of the current literature.

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Published In

Clin Liver Dis

DOI

EISSN

1557-8224

Publication Date

August 2009

Volume

13

Issue

3

Start / End Page

375 / 390

Location

United States

Related Subject Headings

  • RNA, Small Interfering
  • RNA, Catalytic
  • RNA Interference
  • Oligonucleotides, Antisense
  • MicroRNAs
  • Humans
  • Hepatitis C
  • Hepacivirus
  • Gene Expression Regulation, Viral
  • Gastroenterology & Hepatology
 

Citation

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Thompson, A. J. V., & Patel, K. (2009). Antisense inhibitors, ribozymes, and siRNAs. Clin Liver Dis, 13(3), 375–390. https://doi.org/10.1016/j.cld.2009.05.003
Thompson, Alexander J. V., and Keyur Patel. “Antisense inhibitors, ribozymes, and siRNAs.Clin Liver Dis 13, no. 3 (August 2009): 375–90. https://doi.org/10.1016/j.cld.2009.05.003.
Thompson AJV, Patel K. Antisense inhibitors, ribozymes, and siRNAs. Clin Liver Dis. 2009 Aug;13(3):375–90.
Thompson, Alexander J. V., and Keyur Patel. “Antisense inhibitors, ribozymes, and siRNAs.Clin Liver Dis, vol. 13, no. 3, Aug. 2009, pp. 375–90. Pubmed, doi:10.1016/j.cld.2009.05.003.
Thompson AJV, Patel K. Antisense inhibitors, ribozymes, and siRNAs. Clin Liver Dis. 2009 Aug;13(3):375–390.
Journal cover image

Published In

Clin Liver Dis

DOI

EISSN

1557-8224

Publication Date

August 2009

Volume

13

Issue

3

Start / End Page

375 / 390

Location

United States

Related Subject Headings

  • RNA, Small Interfering
  • RNA, Catalytic
  • RNA Interference
  • Oligonucleotides, Antisense
  • MicroRNAs
  • Humans
  • Hepatitis C
  • Hepacivirus
  • Gene Expression Regulation, Viral
  • Gastroenterology & Hepatology