Antisense inhibitors, ribozymes, and siRNAs.
Publication
, Journal Article
Thompson, AJV; Patel, K
Published in: Clin Liver Dis
August 2009
The current standard of care for the treatment of hepatitis C virus infection, pegylated interferon-alpha and ribavirin, is costly, associated with significant side effects, and effective in only 50% of patients. There is therefore a need for the development of novel antiviral therapies. One such approach involves the application of gene silencing technologies, including antisense oligonucleotides, ribozymes, RNA interference, and aptamers. However, despite great scientific advances over the past decade, and promising in vitro data, several significant challenges continue to limit the translation of this technology to the clinical setting. This review provides a concise update of the current literature.
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Published In
Clin Liver Dis
DOI
EISSN
1557-8224
Publication Date
August 2009
Volume
13
Issue
3
Start / End Page
375 / 390
Location
United States
Related Subject Headings
- RNA, Small Interfering
- RNA, Catalytic
- RNA Interference
- Oligonucleotides, Antisense
- MicroRNAs
- Humans
- Hepatitis C
- Hepacivirus
- Gene Expression Regulation, Viral
- Gastroenterology & Hepatology
Citation
APA
Chicago
ICMJE
MLA
NLM
Thompson, A. J. V., & Patel, K. (2009). Antisense inhibitors, ribozymes, and siRNAs. Clin Liver Dis, 13(3), 375–390. https://doi.org/10.1016/j.cld.2009.05.003
Thompson, Alexander J. V., and Keyur Patel. “Antisense inhibitors, ribozymes, and siRNAs.” Clin Liver Dis 13, no. 3 (August 2009): 375–90. https://doi.org/10.1016/j.cld.2009.05.003.
Thompson AJV, Patel K. Antisense inhibitors, ribozymes, and siRNAs. Clin Liver Dis. 2009 Aug;13(3):375–90.
Thompson, Alexander J. V., and Keyur Patel. “Antisense inhibitors, ribozymes, and siRNAs.” Clin Liver Dis, vol. 13, no. 3, Aug. 2009, pp. 375–90. Pubmed, doi:10.1016/j.cld.2009.05.003.
Thompson AJV, Patel K. Antisense inhibitors, ribozymes, and siRNAs. Clin Liver Dis. 2009 Aug;13(3):375–390.
Published In
Clin Liver Dis
DOI
EISSN
1557-8224
Publication Date
August 2009
Volume
13
Issue
3
Start / End Page
375 / 390
Location
United States
Related Subject Headings
- RNA, Small Interfering
- RNA, Catalytic
- RNA Interference
- Oligonucleotides, Antisense
- MicroRNAs
- Humans
- Hepatitis C
- Hepacivirus
- Gene Expression Regulation, Viral
- Gastroenterology & Hepatology