Skip to main content
Journal cover image

Correlation of FIBROSpect II with histologic and morphometric evaluation of liver fibrosis in chronic hepatitis C.

Publication ,  Journal Article
Patel, K; Nelson, DR; Rockey, DC; Afdhal, NH; Smith, KM; Oh, E; Hettinger, K; Vallée, M; Dev, A; Smith-Riggs, M; McHutchison, JG
Published in: Clin Gastroenterol Hepatol
February 2008

BACKGROUND & AIMS: Accurate disease staging in chronic hepatitis C (CHC) infection helps guide treatment and may provide prognostic information. Liver biopsies are invasive, costly, and associated with morbidity. We hypothesized that a noninvasive test of liver fibrosis can accurately stage liver fibrosis. We prospectively evaluated the FIBROSpect II (FSII) biomarker panel versus pathology assessment and a quantitative measure of fibrosis. METHODS: Liver biopsy specimens and serum were obtained from 252 CHC patients, including 50 posttransplant, from 3 tertiary centers. Biopsy specimens were scored centrally and independently at each site, along with central quantification of fibrosis by digitized morphometry. Serum tests were performed blinded to clinical or histologic evaluation. RESULTS: The mean biopsy specimen length was 1.95 +/- 0.87 cm; prevalence of stage F2 through F4 fibrosis was 77%. Agreement between central and site readings for individual stages was modest (k = 0.674), with concordant readings in 106 of 248 (43%) biopsy specimens. The area under the receiver operating characteristic curve for FSII and morphometry for stages F2 through F4 for concordant biopsy specimens were 0.823 and 0.728, respectively. Sensitivity and specificity for FSII were 83.5% and 66.7%, respectively, with an accuracy of 80.2%. The aspartate aminotransferase to platelet ratio index sensitivity and specificity for predicting F2 through F4 were 30.4% and 100%, respectively, the indeterminate rate was 40.4%, and the accuracy rate was 48.4%. The accuracy of FSII in concordant biopsy specimens in the posttransplant cohort was 73%. CONCLUSIONS: Serum biomarkers can differentiate mild from moderate-to-severe fibrosis. This prospective study validates the performance characteristics of FSII in CHC patients and a posttransplant cohort. Assessing the diagnostic utility of biomarkers is limited by variability in methods to quantify fibrosis and poor interobserver agreement for histologic staging.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Clin Gastroenterol Hepatol

DOI

EISSN

1542-7714

Publication Date

February 2008

Volume

6

Issue

2

Start / End Page

242 / 247

Location

United States

Related Subject Headings

  • alpha-Macroglobulins
  • Tissue Inhibitor of Metalloproteinase-1
  • Serum
  • Sensitivity and Specificity
  • Prospective Studies
  • Platelet Count
  • Middle Aged
  • Male
  • Liver Cirrhosis
  • Liver
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Patel, K., Nelson, D. R., Rockey, D. C., Afdhal, N. H., Smith, K. M., Oh, E., … McHutchison, J. G. (2008). Correlation of FIBROSpect II with histologic and morphometric evaluation of liver fibrosis in chronic hepatitis C. Clin Gastroenterol Hepatol, 6(2), 242–247. https://doi.org/10.1016/j.cgh.2007.11.009
Patel, Keyur, David R. Nelson, Don C. Rockey, Nezam H. Afdhal, Katie M. Smith, Esther Oh, Keith Hettinger, et al. “Correlation of FIBROSpect II with histologic and morphometric evaluation of liver fibrosis in chronic hepatitis C.Clin Gastroenterol Hepatol 6, no. 2 (February 2008): 242–47. https://doi.org/10.1016/j.cgh.2007.11.009.
Patel K, Nelson DR, Rockey DC, Afdhal NH, Smith KM, Oh E, et al. Correlation of FIBROSpect II with histologic and morphometric evaluation of liver fibrosis in chronic hepatitis C. Clin Gastroenterol Hepatol. 2008 Feb;6(2):242–7.
Patel, Keyur, et al. “Correlation of FIBROSpect II with histologic and morphometric evaluation of liver fibrosis in chronic hepatitis C.Clin Gastroenterol Hepatol, vol. 6, no. 2, Feb. 2008, pp. 242–47. Pubmed, doi:10.1016/j.cgh.2007.11.009.
Patel K, Nelson DR, Rockey DC, Afdhal NH, Smith KM, Oh E, Hettinger K, Vallée M, Dev A, Smith-Riggs M, McHutchison JG. Correlation of FIBROSpect II with histologic and morphometric evaluation of liver fibrosis in chronic hepatitis C. Clin Gastroenterol Hepatol. 2008 Feb;6(2):242–247.
Journal cover image

Published In

Clin Gastroenterol Hepatol

DOI

EISSN

1542-7714

Publication Date

February 2008

Volume

6

Issue

2

Start / End Page

242 / 247

Location

United States

Related Subject Headings

  • alpha-Macroglobulins
  • Tissue Inhibitor of Metalloproteinase-1
  • Serum
  • Sensitivity and Specificity
  • Prospective Studies
  • Platelet Count
  • Middle Aged
  • Male
  • Liver Cirrhosis
  • Liver