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Clinical Utility of Biomarkers of Liver Fibrosis.

Publication ,  Journal Article
Patel, K; Rockey, DC
Published in: Gastroenterol Hepatol (N Y)
January 2006

Hepatic fibrogenesis is a dynamic process and reflects a balance between matrix synthesis and degradation. An accurate determination of hepatic fibrosis in chronic liver disease is important in determining prognosis, therapy outcomes, and disease progression. Needle liver biopsy is an invasive procedure that is associated with small sample size and inaccurate staging, and provides only a semiquantitative assessment of fibrosis. A number of simple and specific extracellular matrix biochemical markers predictive of fibrosis have been developed and validated in patients with chronic liver disease. Further improvements in these noninvasive approaches, incorporating emerging technologies such as proteomics and transient elastography, will likely provide more accurate and reliable measures of disease severity in these patients.

Duke Scholars

Published In

Gastroenterol Hepatol (N Y)

ISSN

1554-7914

Publication Date

January 2006

Volume

2

Issue

1

Start / End Page

48 / 57

Location

United States

Related Subject Headings

  • Gastroenterology & Hepatology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Patel, K., & Rockey, D. C. (2006). Clinical Utility of Biomarkers of Liver Fibrosis. Gastroenterol Hepatol (N Y), 2(1), 48–57.
Patel, Keyur, and Don C. Rockey. “Clinical Utility of Biomarkers of Liver Fibrosis.Gastroenterol Hepatol (N Y) 2, no. 1 (January 2006): 48–57.
Patel K, Rockey DC. Clinical Utility of Biomarkers of Liver Fibrosis. Gastroenterol Hepatol (N Y). 2006 Jan;2(1):48–57.
Patel, Keyur, and Don C. Rockey. “Clinical Utility of Biomarkers of Liver Fibrosis.Gastroenterol Hepatol (N Y), vol. 2, no. 1, Jan. 2006, pp. 48–57.
Patel K, Rockey DC. Clinical Utility of Biomarkers of Liver Fibrosis. Gastroenterol Hepatol (N Y). 2006 Jan;2(1):48–57.

Published In

Gastroenterol Hepatol (N Y)

ISSN

1554-7914

Publication Date

January 2006

Volume

2

Issue

1

Start / End Page

48 / 57

Location

United States

Related Subject Headings

  • Gastroenterology & Hepatology