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Risks of a range of alcohol intake on hepatitis C-related fibrosis.

Publication ,  Journal Article
Monto, A; Patel, K; Bostrom, A; Pianko, S; Pockros, P; McHutchison, JG; Wright, TL
Published in: Hepatology
March 2004

Heavy alcohol use contributes to liver disease in the setting of chronic hepatitis C virus (HCV) infection. Whether this is true for light or moderate alcohol use has not been demonstrated. Light alcohol use has survival benefits at a population level and is practiced by most patients with chronic HCV infection. In this study, 800 patients with HCV undergoing liver biopsy at three sites had detailed alcohol histories recorded and the relationship between alcohol and hepatic fibrosis was assessed. On univariate analysis, heavy alcohol use (>50 g/day) was associated with an increase in mean fibrosis (P =.01). Such an association could not be demonstrated for light and moderate alcohol use. For each category of alcohol intake (none, light, moderate, and heavy), a spectrum of fibrosis was observed. On multivariate analysis, age, serum alanine aminotransferase (ALT), and histological inflammation were the independent predictors of fibrosis (P = <.0001,.0003, <.0001, respectively). In conclusion, heavy alcohol use exerts a greater effect on fibrosis than light or moderate use. There is a range of fibrosis at each level of alcohol use. Age, serum ALT, and inflammation are independently associated with fibrosis in multivariate analysis, highlighting the fact that variables other than alcohol intake predominate in the production of hepatic fibrosis.

Duke Scholars

Published In

Hepatology

DOI

ISSN

0270-9139

Publication Date

March 2004

Volume

39

Issue

3

Start / End Page

826 / 834

Location

United States

Related Subject Headings

  • Risk Assessment
  • Multivariate Analysis
  • Liver Cirrhosis
  • Humans
  • Hepatitis C
  • Gastroenterology & Hepatology
  • Dose-Response Relationship, Drug
  • Cohort Studies
  • Biopsy
  • Alcohol Drinking
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Monto, A., Patel, K., Bostrom, A., Pianko, S., Pockros, P., McHutchison, J. G., & Wright, T. L. (2004). Risks of a range of alcohol intake on hepatitis C-related fibrosis. Hepatology, 39(3), 826–834. https://doi.org/10.1002/hep.20127
Monto, Alexander, Keyur Patel, Alan Bostrom, Stephen Pianko, Paul Pockros, John G. McHutchison, and Teresa L. Wright. “Risks of a range of alcohol intake on hepatitis C-related fibrosis.Hepatology 39, no. 3 (March 2004): 826–34. https://doi.org/10.1002/hep.20127.
Monto A, Patel K, Bostrom A, Pianko S, Pockros P, McHutchison JG, et al. Risks of a range of alcohol intake on hepatitis C-related fibrosis. Hepatology. 2004 Mar;39(3):826–34.
Monto, Alexander, et al. “Risks of a range of alcohol intake on hepatitis C-related fibrosis.Hepatology, vol. 39, no. 3, Mar. 2004, pp. 826–34. Pubmed, doi:10.1002/hep.20127.
Monto A, Patel K, Bostrom A, Pianko S, Pockros P, McHutchison JG, Wright TL. Risks of a range of alcohol intake on hepatitis C-related fibrosis. Hepatology. 2004 Mar;39(3):826–834.
Journal cover image

Published In

Hepatology

DOI

ISSN

0270-9139

Publication Date

March 2004

Volume

39

Issue

3

Start / End Page

826 / 834

Location

United States

Related Subject Headings

  • Risk Assessment
  • Multivariate Analysis
  • Liver Cirrhosis
  • Humans
  • Hepatitis C
  • Gastroenterology & Hepatology
  • Dose-Response Relationship, Drug
  • Cohort Studies
  • Biopsy
  • Alcohol Drinking