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New therapies for chronic hepatitis C virus infection.

Publication ,  Journal Article
Dev, A; Patel, K; McHutchison, JG
Published in: Curr Gastroenterol Rep
February 2004

Chronic hepatitis C infection is associated with significant morbidity and mortality in addition to substantial social and health-related costs. Since the identification of the virus and determination of the HCV genome over a decade ago, considerable progress has been made in the treatment of chronic hepatitis C infection. However, the current standard combination of interferon-based therapies and ribavirin is effective in only 50% of patients. In addition, this combination is expensive, requires lengthy periods of administration, and is associated with significant side effects. Furthermore, no effective preventive measure, such as vaccination, is currently available. A number of newer therapies, including protease and helicase inhibitors, ribozymes, antisense therapies, and therapeutic vaccines, are in preclinical and clinical development and may significantly enhance existing therapeutic options for the future.

Duke Scholars

Published In

Curr Gastroenterol Rep

DOI

ISSN

1522-8037

Publication Date

February 2004

Volume

6

Issue

1

Start / End Page

77 / 86

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Survival Analysis
  • Severity of Illness Index
  • Risk Assessment
  • Ribavirin
  • Recombinant Proteins
  • Randomized Controlled Trials as Topic
  • Male
  • Liver Function Tests
  • Interferon-alpha
 

Citation

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Dev, A., Patel, K., & McHutchison, J. G. (2004). New therapies for chronic hepatitis C virus infection. Curr Gastroenterol Rep, 6(1), 77–86. https://doi.org/10.1007/s11894-004-0030-5
Dev, Anouk, Keyur Patel, and John G. McHutchison. “New therapies for chronic hepatitis C virus infection.Curr Gastroenterol Rep 6, no. 1 (February 2004): 77–86. https://doi.org/10.1007/s11894-004-0030-5.
Dev A, Patel K, McHutchison JG. New therapies for chronic hepatitis C virus infection. Curr Gastroenterol Rep. 2004 Feb;6(1):77–86.
Dev, Anouk, et al. “New therapies for chronic hepatitis C virus infection.Curr Gastroenterol Rep, vol. 6, no. 1, Feb. 2004, pp. 77–86. Pubmed, doi:10.1007/s11894-004-0030-5.
Dev A, Patel K, McHutchison JG. New therapies for chronic hepatitis C virus infection. Curr Gastroenterol Rep. 2004 Feb;6(1):77–86.
Journal cover image

Published In

Curr Gastroenterol Rep

DOI

ISSN

1522-8037

Publication Date

February 2004

Volume

6

Issue

1

Start / End Page

77 / 86

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Survival Analysis
  • Severity of Illness Index
  • Risk Assessment
  • Ribavirin
  • Recombinant Proteins
  • Randomized Controlled Trials as Topic
  • Male
  • Liver Function Tests
  • Interferon-alpha