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Radiographic imaging of bronchioloalveolar carcinoma: Screening, patterns of presentation and response assessment

Publication ,  Journal Article
Gandara, DR; Aberle, D; Lau, D; Jett, J; Akhurst, T; Mulshine, J; Berg, C; Patz, EF
Published in: Journal of Thoracic Oncology
January 1, 2006

Bronchioloalveolar carcinoma (BAC) is a previously uncommon subset of adenocarcinoma with unique epidemiology, pathology, radiographic presentation, clinical features, and natural history compared with other non-small cell lung cancer (NSCLC) subtypes. Classically, BAC demonstrates a relatively slow growth pattern and indolent clinical course. However, in a subset of patients, rapid growth and death from bilateral diffuse consolidative disease occurs within months of diagnosis or recurrence. Recent data suggest that the incidence of BAC is increasing, notably in younger nonsmoking women. The initial radiographic presentation of BAC varies considerably, from single ground glass opacities (GGOs) or nodules of mixed ground glass and solid attenuation to diffuse consolidative or bilateral multinodular disease. The rising incidence of BAC is also reflected in recent lung cancer screening studies employing helical computed tomography (CT), where the differential diagnosis of GGOs includes not only BAC and overt adenocarcinoma, but inflammatory disease, focal fibrosis, and atypical adenomatous hyperplasia. Because advanced-stage BAC presents as measurable mass lesions in fewer than 50% of cases, determination of radiographic response to therapy by standard criteria is often difficult. Here, we review current data regarding the radiographic imaging of BAC: its radiographic presentations in asymptomatic early-stage and in advanced-stage disease, the functional imaging characteristics of BAC, and challenges of response assessment, including evolving opportunities for computer-assisted image analysis. © 2006International Association for the Study of Lung Cancer.

Duke Scholars

Published In

Journal of Thoracic Oncology

DOI

EISSN

1556-1380

ISSN

1556-0864

Publication Date

January 1, 2006

Volume

1

Issue

9 SUPPL.

Related Subject Headings

  • Oncology & Carcinogenesis
  • 3211 Oncology and carcinogenesis
  • 3202 Clinical sciences
  • 1112 Oncology and Carcinogenesis
  • 1103 Clinical Sciences
  • 1102 Cardiorespiratory Medicine and Haematology
 

Citation

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MLA
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Gandara, D. R., Aberle, D., Lau, D., Jett, J., Akhurst, T., Mulshine, J., … Patz, E. F. (2006). Radiographic imaging of bronchioloalveolar carcinoma: Screening, patterns of presentation and response assessment. Journal of Thoracic Oncology, 1(9 SUPPL.). https://doi.org/10.1016/s1556-0864(15)30005-8
Gandara, D. R., D. Aberle, D. Lau, J. Jett, T. Akhurst, J. Mulshine, C. Berg, and E. F. Patz. “Radiographic imaging of bronchioloalveolar carcinoma: Screening, patterns of presentation and response assessment.” Journal of Thoracic Oncology 1, no. 9 SUPPL. (January 1, 2006). https://doi.org/10.1016/s1556-0864(15)30005-8.
Gandara DR, Aberle D, Lau D, Jett J, Akhurst T, Mulshine J, et al. Radiographic imaging of bronchioloalveolar carcinoma: Screening, patterns of presentation and response assessment. Journal of Thoracic Oncology. 2006 Jan 1;1(9 SUPPL.).
Gandara, D. R., et al. “Radiographic imaging of bronchioloalveolar carcinoma: Screening, patterns of presentation and response assessment.” Journal of Thoracic Oncology, vol. 1, no. 9 SUPPL., Jan. 2006. Scopus, doi:10.1016/s1556-0864(15)30005-8.
Gandara DR, Aberle D, Lau D, Jett J, Akhurst T, Mulshine J, Berg C, Patz EF. Radiographic imaging of bronchioloalveolar carcinoma: Screening, patterns of presentation and response assessment. Journal of Thoracic Oncology. 2006 Jan 1;1(9 SUPPL.).
Journal cover image

Published In

Journal of Thoracic Oncology

DOI

EISSN

1556-1380

ISSN

1556-0864

Publication Date

January 1, 2006

Volume

1

Issue

9 SUPPL.

Related Subject Headings

  • Oncology & Carcinogenesis
  • 3211 Oncology and carcinogenesis
  • 3202 Clinical sciences
  • 1112 Oncology and Carcinogenesis
  • 1103 Clinical Sciences
  • 1102 Cardiorespiratory Medicine and Haematology