Transient mild hypothermia differentially alters mitotic activity in normal and post-ischemic hippocampal slices from neonatal rats
Publication
, Journal Article
Finch, AS; Moldovan, M; Frank, J; Bagnell, R; Katz, LM; Pearlstein, RD
Published in: Journal of Thermal Biology
May 1, 2010
The purpose of this study was to determine if mild hypothermia alters mitotic activity in normal and post-ischemic hippocampal slices. (1) Normothermic oxygen-glucose deprivation (OGD 60 min) increased mitotic activity in the hippocampus up to 4d post-OGD. (2) Mild hypothermia (33 °C for 24 h) initiated after OGD stress reduced mitotic activity compared to normothermic controls up to 8 d post-OGD. (3) Mild hypothermia stimulated mitotic activity in normal (no OGD stress) hippocampus up to 24 h post-hypothermia. In conclusion, mild transient hypothermia can increase or decrease mitotic activity depending upon the experimental condition of the hippocampal slices when hypothermia is induced. © 2010 Elsevier Ltd.
Duke Scholars
Published In
Journal of Thermal Biology
DOI
ISSN
0306-4565
Publication Date
May 1, 2010
Volume
35
Issue
4
Start / End Page
189 / 196
Related Subject Headings
- Physiology
- 3109 Zoology
- 06 Biological Sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Finch, A. S., Moldovan, M., Frank, J., Bagnell, R., Katz, L. M., & Pearlstein, R. D. (2010). Transient mild hypothermia differentially alters mitotic activity in normal and post-ischemic hippocampal slices from neonatal rats. Journal of Thermal Biology, 35(4), 189–196. https://doi.org/10.1016/j.jtherbio.2010.03.003
Finch, A. S., M. Moldovan, J. Frank, R. Bagnell, L. M. Katz, and R. D. Pearlstein. “Transient mild hypothermia differentially alters mitotic activity in normal and post-ischemic hippocampal slices from neonatal rats.” Journal of Thermal Biology 35, no. 4 (May 1, 2010): 189–96. https://doi.org/10.1016/j.jtherbio.2010.03.003.
Finch AS, Moldovan M, Frank J, Bagnell R, Katz LM, Pearlstein RD. Transient mild hypothermia differentially alters mitotic activity in normal and post-ischemic hippocampal slices from neonatal rats. Journal of Thermal Biology. 2010 May 1;35(4):189–96.
Finch, A. S., et al. “Transient mild hypothermia differentially alters mitotic activity in normal and post-ischemic hippocampal slices from neonatal rats.” Journal of Thermal Biology, vol. 35, no. 4, May 2010, pp. 189–96. Scopus, doi:10.1016/j.jtherbio.2010.03.003.
Finch AS, Moldovan M, Frank J, Bagnell R, Katz LM, Pearlstein RD. Transient mild hypothermia differentially alters mitotic activity in normal and post-ischemic hippocampal slices from neonatal rats. Journal of Thermal Biology. 2010 May 1;35(4):189–196.
Published In
Journal of Thermal Biology
DOI
ISSN
0306-4565
Publication Date
May 1, 2010
Volume
35
Issue
4
Start / End Page
189 / 196
Related Subject Headings
- Physiology
- 3109 Zoology
- 06 Biological Sciences