Skip to main content

Structure-in vitro activity relationships of pentamidine analogues and dication-substituted bis-benzimidazoles as new antifungal agents.

Publication ,  Journal Article
Del Poeta, M; Schell, WA; Dykstra, CC; Jones, S; Tidwell, RR; Czarny, A; Bajic, M; Kumar, A; Boykin, D; Perfect, JR
Published in: Antimicrob Agents Chemother
October 1998

Twenty analogues of pentamidine, 7 primary metabolites of pentamidine, and 30 dicationic substituted bis-benzimidazoles were screened for their inhibitory and fungicidal activities against Candida albicans and Cryptococcus neoformans. A majority of the compounds had MICs at which 80% of the strains were inhibited (MIC80s) comparable to those of amphotericin B and fluconazole. Unlike fluconazole, many of these compounds were found to have potent fungicidal activity. The most potent compound against C. albicans had an MIC80 of

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Antimicrob Agents Chemother

DOI

ISSN

0066-4804

Publication Date

October 1998

Volume

42

Issue

10

Start / End Page

2495 / 2502

Location

United States

Related Subject Headings

  • Structure-Activity Relationship
  • Pentamidine
  • Microbiology
  • Microbial Sensitivity Tests
  • Benzimidazoles
  • Antifungal Agents
  • 3214 Pharmacology and pharmaceutical sciences
  • 3207 Medical microbiology
  • 3107 Microbiology
  • 1115 Pharmacology and Pharmaceutical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Del Poeta, M., Schell, W. A., Dykstra, C. C., Jones, S., Tidwell, R. R., Czarny, A., … Perfect, J. R. (1998). Structure-in vitro activity relationships of pentamidine analogues and dication-substituted bis-benzimidazoles as new antifungal agents. Antimicrob Agents Chemother, 42(10), 2495–2502. https://doi.org/10.1128/AAC.42.10.2495
Del Poeta, M., W. A. Schell, C. C. Dykstra, S. Jones, R. R. Tidwell, A. Czarny, M. Bajic, A. Kumar, D. Boykin, and J. R. Perfect. “Structure-in vitro activity relationships of pentamidine analogues and dication-substituted bis-benzimidazoles as new antifungal agents.Antimicrob Agents Chemother 42, no. 10 (October 1998): 2495–2502. https://doi.org/10.1128/AAC.42.10.2495.
Del Poeta M, Schell WA, Dykstra CC, Jones S, Tidwell RR, Czarny A, et al. Structure-in vitro activity relationships of pentamidine analogues and dication-substituted bis-benzimidazoles as new antifungal agents. Antimicrob Agents Chemother. 1998 Oct;42(10):2495–502.
Del Poeta, M., et al. “Structure-in vitro activity relationships of pentamidine analogues and dication-substituted bis-benzimidazoles as new antifungal agents.Antimicrob Agents Chemother, vol. 42, no. 10, Oct. 1998, pp. 2495–502. Pubmed, doi:10.1128/AAC.42.10.2495.
Del Poeta M, Schell WA, Dykstra CC, Jones S, Tidwell RR, Czarny A, Bajic M, Kumar A, Boykin D, Perfect JR. Structure-in vitro activity relationships of pentamidine analogues and dication-substituted bis-benzimidazoles as new antifungal agents. Antimicrob Agents Chemother. 1998 Oct;42(10):2495–2502.

Published In

Antimicrob Agents Chemother

DOI

ISSN

0066-4804

Publication Date

October 1998

Volume

42

Issue

10

Start / End Page

2495 / 2502

Location

United States

Related Subject Headings

  • Structure-Activity Relationship
  • Pentamidine
  • Microbiology
  • Microbial Sensitivity Tests
  • Benzimidazoles
  • Antifungal Agents
  • 3214 Pharmacology and pharmaceutical sciences
  • 3207 Medical microbiology
  • 3107 Microbiology
  • 1115 Pharmacology and Pharmaceutical Sciences