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In vitro antifungal activities of a series of dication-substituted carbazoles, furans, and benzimidazoles.

Publication ,  Journal Article
Del Poeta, M; Schell, WA; Dykstra, CC; Jones, SK; Tidwell, RR; Kumar, A; Boykin, DW; Perfect, JR
Published in: Antimicrob Agents Chemother
October 1998

Aromatic dicationic compounds possess antimicrobial activity against a wide range of eucaryotic pathogens, and in the present study an examination of the structures-functions of a series of compounds against fungi was performed. Sixty-seven dicationic molecules were screened for their inhibitory and fungicidal activities against Candida albicans and Cryptococcus neoformans. The MICs of a large number of compounds were comparable to those of the standard antifungal drugs amphotericin B and fluconazole. Unlike fluconazole, potent inhibitory compounds in this series were found to have excellent fungicidal activities. The MIC of one of the most potent compounds against C. albicans was 0.39 microg/ml, and it was the most potent compound against C. neoformans (MIC,

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Published In

Antimicrob Agents Chemother

DOI

ISSN

0066-4804

Publication Date

October 1998

Volume

42

Issue

10

Start / End Page

2503 / 2510

Location

United States

Related Subject Headings

  • Structure-Activity Relationship
  • Microbiology
  • Microbial Sensitivity Tests
  • Furans
  • DNA
  • Carbazoles
  • Benzimidazoles
  • Antifungal Agents
  • 3214 Pharmacology and pharmaceutical sciences
  • 3207 Medical microbiology
 

Citation

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Del Poeta, M., Schell, W. A., Dykstra, C. C., Jones, S. K., Tidwell, R. R., Kumar, A., … Perfect, J. R. (1998). In vitro antifungal activities of a series of dication-substituted carbazoles, furans, and benzimidazoles. Antimicrob Agents Chemother, 42(10), 2503–2510. https://doi.org/10.1128/AAC.42.10.2503
Del Poeta, M., W. A. Schell, C. C. Dykstra, S. K. Jones, R. R. Tidwell, A. Kumar, D. W. Boykin, and J. R. Perfect. “In vitro antifungal activities of a series of dication-substituted carbazoles, furans, and benzimidazoles.Antimicrob Agents Chemother 42, no. 10 (October 1998): 2503–10. https://doi.org/10.1128/AAC.42.10.2503.
Del Poeta M, Schell WA, Dykstra CC, Jones SK, Tidwell RR, Kumar A, et al. In vitro antifungal activities of a series of dication-substituted carbazoles, furans, and benzimidazoles. Antimicrob Agents Chemother. 1998 Oct;42(10):2503–10.
Del Poeta, M., et al. “In vitro antifungal activities of a series of dication-substituted carbazoles, furans, and benzimidazoles.Antimicrob Agents Chemother, vol. 42, no. 10, Oct. 1998, pp. 2503–10. Pubmed, doi:10.1128/AAC.42.10.2503.
Del Poeta M, Schell WA, Dykstra CC, Jones SK, Tidwell RR, Kumar A, Boykin DW, Perfect JR. In vitro antifungal activities of a series of dication-substituted carbazoles, furans, and benzimidazoles. Antimicrob Agents Chemother. 1998 Oct;42(10):2503–2510.

Published In

Antimicrob Agents Chemother

DOI

ISSN

0066-4804

Publication Date

October 1998

Volume

42

Issue

10

Start / End Page

2503 / 2510

Location

United States

Related Subject Headings

  • Structure-Activity Relationship
  • Microbiology
  • Microbial Sensitivity Tests
  • Furans
  • DNA
  • Carbazoles
  • Benzimidazoles
  • Antifungal Agents
  • 3214 Pharmacology and pharmaceutical sciences
  • 3207 Medical microbiology