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Infection and cyclosporine.

Publication ,  Journal Article
Kim, JH; Perfect, JR
Published in: Rev Infect Dis
1989

Cyclosporine is a potent immunosuppressive agent that selectively impairs T cell function. The steady growth of its importance makes knowledge of its activity and effects clinically relevant. The intrinsic antibiotic activity of cyclosporine is limited; although it inhibits certain viruses, fungi, protozoa, and helminths, in practical terms these effects are insignificant. Both controlled and noncontrolled studies have shown that infection is an infrequent problem in patients with autoimmune diseases who are receiving relatively low doses. The use of cyclosporine in the setting of transplantation does not increase--and may in fact decrease--the incidence of infection in comparison with that during standard immunosuppressive therapy. Fungal, viral, and bacterial diseases remain a risk, however, and are a significant cause of morbidity in this population. Antimicrobial therapy may alter cyclosporine levels and cause nephrotoxicity or graft rejection. Careful monitoring of cyclosporine levels during antimicrobial treatment is therefore recommended.

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Published In

Rev Infect Dis

DOI

ISSN

0162-0886

Publication Date

1989

Volume

11

Issue

5

Start / End Page

677 / 690

Location

United States

Related Subject Headings

  • Transplantation
  • Infections
  • Immunosuppression Therapy
  • Humans
  • Drug Interactions
  • Cyclosporins
  • Autoimmune Diseases
  • Anti-Infective Agents
  • Animals
 

Citation

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Kim, J. H., & Perfect, J. R. (1989). Infection and cyclosporine. Rev Infect Dis, 11(5), 677–690. https://doi.org/10.1093/clinids/11.5.677
Kim, J. H., and J. R. Perfect. “Infection and cyclosporine.Rev Infect Dis 11, no. 5 (1989): 677–90. https://doi.org/10.1093/clinids/11.5.677.
Kim JH, Perfect JR. Infection and cyclosporine. Rev Infect Dis. 1989;11(5):677–90.
Kim, J. H., and J. R. Perfect. “Infection and cyclosporine.Rev Infect Dis, vol. 11, no. 5, 1989, pp. 677–90. Pubmed, doi:10.1093/clinids/11.5.677.
Kim JH, Perfect JR. Infection and cyclosporine. Rev Infect Dis. 1989;11(5):677–690.

Published In

Rev Infect Dis

DOI

ISSN

0162-0886

Publication Date

1989

Volume

11

Issue

5

Start / End Page

677 / 690

Location

United States

Related Subject Headings

  • Transplantation
  • Infections
  • Immunosuppression Therapy
  • Humans
  • Drug Interactions
  • Cyclosporins
  • Autoimmune Diseases
  • Anti-Infective Agents
  • Animals