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Reciprocal uniparental disomy in yeast.

Publication ,  Journal Article
Andersen, SL; Petes, TD
Published in: Proc Natl Acad Sci U S A
June 19, 2012

In the diploid cells of most organisms, including humans, each chromosome is usually distinguishable from its partner homolog by multiple single-nucleotide polymorphisms. One common type of genetic alteration observed in tumor cells is uniparental disomy (UPD), in which a pair of homologous chromosomes are derived from a single parent, resulting in loss of heterozygosity for all single-nucleotide polymorphisms while maintaining diploidy. Somatic UPD events are usually explained as reflecting two consecutive nondisjunction events. Here we report a previously undescribed mode of chromosome segregation in Saccharomyces cerevisiae in which one cell division produces daughter cells with reciprocal UPD for the same pair of chromosomes without an aneuploid intermediate. One pair of sister chromatids is segregated into one daughter cell and the other pair is segregated into the other daughter cell, mimicking a meiotic chromosome segregation pattern. We term this process "reciprocal uniparental disomy."

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Published In

Proc Natl Acad Sci U S A

DOI

EISSN

1091-6490

Publication Date

June 19, 2012

Volume

109

Issue

25

Start / End Page

9947 / 9952

Location

United States

Related Subject Headings

  • Uniparental Disomy
  • Saccharomyces cerevisiae
  • Polymorphism, Single Nucleotide
  • Oligonucleotide Array Sequence Analysis
  • Loss of Heterozygosity
  • Genomic Instability
  • DNA Primers
  • Chromosomes, Fungal
  • Base Sequence
 

Citation

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Andersen, S. L., & Petes, T. D. (2012). Reciprocal uniparental disomy in yeast. Proc Natl Acad Sci U S A, 109(25), 9947–9952. https://doi.org/10.1073/pnas.1207736109
Andersen, Sabrina L., and Thomas D. Petes. “Reciprocal uniparental disomy in yeast.Proc Natl Acad Sci U S A 109, no. 25 (June 19, 2012): 9947–52. https://doi.org/10.1073/pnas.1207736109.
Andersen SL, Petes TD. Reciprocal uniparental disomy in yeast. Proc Natl Acad Sci U S A. 2012 Jun 19;109(25):9947–52.
Andersen, Sabrina L., and Thomas D. Petes. “Reciprocal uniparental disomy in yeast.Proc Natl Acad Sci U S A, vol. 109, no. 25, June 2012, pp. 9947–52. Pubmed, doi:10.1073/pnas.1207736109.
Andersen SL, Petes TD. Reciprocal uniparental disomy in yeast. Proc Natl Acad Sci U S A. 2012 Jun 19;109(25):9947–9952.
Journal cover image

Published In

Proc Natl Acad Sci U S A

DOI

EISSN

1091-6490

Publication Date

June 19, 2012

Volume

109

Issue

25

Start / End Page

9947 / 9952

Location

United States

Related Subject Headings

  • Uniparental Disomy
  • Saccharomyces cerevisiae
  • Polymorphism, Single Nucleotide
  • Oligonucleotide Array Sequence Analysis
  • Loss of Heterozygosity
  • Genomic Instability
  • DNA Primers
  • Chromosomes, Fungal
  • Base Sequence