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Regulation of genome stability by TEL1 and MEC1, yeast homologs of the mammalian ATM and ATR genes.

Publication ,  Journal Article
Craven, RJ; Greenwell, PW; Dominska, M; Petes, TD
Published in: Genetics
June 2002

In eukaryotes, a family of related protein kinases (the ATM family) is involved in regulating cellular responses to DNA damage and telomere length. In the yeast Saccharomyces cerevisiae, two members of this family, TEL1 and MEC1, have functionally redundant roles in both DNA damage repair and telomere length regulation. Strains with mutations in both genes are very sensitive to DNA damaging agents, have very short telomeres, and undergo cellular senescence. We find that strains with the double mutant genotype also have approximately 80-fold increased rates of mitotic recombination and chromosome loss. In addition, the tel1 mec1 strains have high rates of telomeric fusions, resulting in translocations, dicentrics, and circular chromosomes. Similar chromosome rearrangements have been detected in mammalian cells with mutations in ATM (related to TEL1) and ATR (related to MEC1) and in mammalian cells that approach cell crisis.

Duke Scholars

Published In

Genetics

DOI

ISSN

0016-6731

Publication Date

June 2002

Volume

161

Issue

2

Start / End Page

493 / 507

Location

United States

Related Subject Headings

  • Saccharomyces cerevisiae Proteins
  • Saccharomyces cerevisiae
  • Recombination, Genetic
  • Protein Serine-Threonine Kinases
  • Polymerase Chain Reaction
  • Phenotype
  • Mutation
  • Intracellular Signaling Peptides and Proteins
  • Genome, Fungal
  • Fungal Proteins
 

Citation

APA
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ICMJE
MLA
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Craven, R. J., Greenwell, P. W., Dominska, M., & Petes, T. D. (2002). Regulation of genome stability by TEL1 and MEC1, yeast homologs of the mammalian ATM and ATR genes. Genetics, 161(2), 493–507. https://doi.org/10.1093/genetics/161.2.493
Craven, Rolf J., Patricia W. Greenwell, Margaret Dominska, and Thomas D. Petes. “Regulation of genome stability by TEL1 and MEC1, yeast homologs of the mammalian ATM and ATR genes.Genetics 161, no. 2 (June 2002): 493–507. https://doi.org/10.1093/genetics/161.2.493.
Craven RJ, Greenwell PW, Dominska M, Petes TD. Regulation of genome stability by TEL1 and MEC1, yeast homologs of the mammalian ATM and ATR genes. Genetics. 2002 Jun;161(2):493–507.
Craven, Rolf J., et al. “Regulation of genome stability by TEL1 and MEC1, yeast homologs of the mammalian ATM and ATR genes.Genetics, vol. 161, no. 2, June 2002, pp. 493–507. Pubmed, doi:10.1093/genetics/161.2.493.
Craven RJ, Greenwell PW, Dominska M, Petes TD. Regulation of genome stability by TEL1 and MEC1, yeast homologs of the mammalian ATM and ATR genes. Genetics. 2002 Jun;161(2):493–507.

Published In

Genetics

DOI

ISSN

0016-6731

Publication Date

June 2002

Volume

161

Issue

2

Start / End Page

493 / 507

Location

United States

Related Subject Headings

  • Saccharomyces cerevisiae Proteins
  • Saccharomyces cerevisiae
  • Recombination, Genetic
  • Protein Serine-Threonine Kinases
  • Polymerase Chain Reaction
  • Phenotype
  • Mutation
  • Intracellular Signaling Peptides and Proteins
  • Genome, Fungal
  • Fungal Proteins