Destabilization of simple repetitive DNA sequences by transcription in yeast.
Publication
, Journal Article
Wierdl, M; Greene, CN; Datta, A; Jinks-Robertson, S; Petes, TD
Published in: Genetics
June 1996
Simple repetitive DNA sequences in the eukaryotic genome frequently alter in length. In wild-type strains, we find that transcription through a repetitive poly GT tract destabilizes the tract four- to ninefold. In mismatch repair-deficient yeast strains, simple repeats are very unstable. High levels of transcription in such strains destabilize repetitive tracts an additional two- to threefold.
Duke Scholars
Published In
Genetics
DOI
ISSN
0016-6731
Publication Date
June 1996
Volume
143
Issue
2
Start / End Page
713 / 721
Location
United States
Related Subject Headings
- Transcription, Genetic
- Sequence Analysis, DNA
- Saccharomyces cerevisiae
- Repetitive Sequences, Nucleic Acid
- Developmental Biology
- DNA, Fungal
- DNA Repair
- DNA Damage
- 3105 Genetics
- 3101 Biochemistry and cell biology
Citation
APA
Chicago
ICMJE
MLA
NLM
Wierdl, M., Greene, C. N., Datta, A., Jinks-Robertson, S., & Petes, T. D. (1996). Destabilization of simple repetitive DNA sequences by transcription in yeast. Genetics, 143(2), 713–721. https://doi.org/10.1093/genetics/143.2.713
Wierdl, M., C. N. Greene, A. Datta, S. Jinks-Robertson, and T. D. Petes. “Destabilization of simple repetitive DNA sequences by transcription in yeast.” Genetics 143, no. 2 (June 1996): 713–21. https://doi.org/10.1093/genetics/143.2.713.
Wierdl M, Greene CN, Datta A, Jinks-Robertson S, Petes TD. Destabilization of simple repetitive DNA sequences by transcription in yeast. Genetics. 1996 Jun;143(2):713–21.
Wierdl, M., et al. “Destabilization of simple repetitive DNA sequences by transcription in yeast.” Genetics, vol. 143, no. 2, June 1996, pp. 713–21. Pubmed, doi:10.1093/genetics/143.2.713.
Wierdl M, Greene CN, Datta A, Jinks-Robertson S, Petes TD. Destabilization of simple repetitive DNA sequences by transcription in yeast. Genetics. 1996 Jun;143(2):713–721.
Published In
Genetics
DOI
ISSN
0016-6731
Publication Date
June 1996
Volume
143
Issue
2
Start / End Page
713 / 721
Location
United States
Related Subject Headings
- Transcription, Genetic
- Sequence Analysis, DNA
- Saccharomyces cerevisiae
- Repetitive Sequences, Nucleic Acid
- Developmental Biology
- DNA, Fungal
- DNA Repair
- DNA Damage
- 3105 Genetics
- 3101 Biochemistry and cell biology