The stabilization of repetitive tracts of DNA by variant repeats requires a functional DNA mismatch repair system.
Publication
, Journal Article
Heale, SM; Petes, TD
Published in: Cell
November 17, 1995
Simple repetitive tracts of DNA are unstable in all organisms thus far examined. In the yeast S. cerevisiae, we show that a 51 bp poly(GT) tract alters length at a rate of about 10(-5) per cell division. Insertion of a single variant repeat (either AT or CT) into the middle of the poly(GT) tract results in 100-fold stabilization. This stabilization requires the DNA mismatch repair system. Alterations within tracts with variant repeats occur more frequently on one side of the interruption than on the other. The stabilizing effects of variant repeats and polarity of repeat alterations have also been observed in trinucleotide repeats associated with certain human diseases.
Duke Scholars
Published In
Cell
DOI
ISSN
0092-8674
Publication Date
November 17, 1995
Volume
83
Issue
4
Start / End Page
539 / 545
Location
United States
Related Subject Headings
- Yeasts
- Repetitive Sequences, Nucleic Acid
- Molecular Sequence Data
- Genotype
- Developmental Biology
- DNA-Directed DNA Polymerase
- DNA Repair
- Base Sequence
- 32 Biomedical and clinical sciences
- 31 Biological sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Heale, S. M., & Petes, T. D. (1995). The stabilization of repetitive tracts of DNA by variant repeats requires a functional DNA mismatch repair system. Cell, 83(4), 539–545. https://doi.org/10.1016/0092-8674(95)90093-4
Heale, S. M., and T. D. Petes. “The stabilization of repetitive tracts of DNA by variant repeats requires a functional DNA mismatch repair system.” Cell 83, no. 4 (November 17, 1995): 539–45. https://doi.org/10.1016/0092-8674(95)90093-4.
Heale SM, Petes TD. The stabilization of repetitive tracts of DNA by variant repeats requires a functional DNA mismatch repair system. Cell. 1995 Nov 17;83(4):539–45.
Heale, S. M., and T. D. Petes. “The stabilization of repetitive tracts of DNA by variant repeats requires a functional DNA mismatch repair system.” Cell, vol. 83, no. 4, Nov. 1995, pp. 539–45. Pubmed, doi:10.1016/0092-8674(95)90093-4.
Heale SM, Petes TD. The stabilization of repetitive tracts of DNA by variant repeats requires a functional DNA mismatch repair system. Cell. 1995 Nov 17;83(4):539–545.
Published In
Cell
DOI
ISSN
0092-8674
Publication Date
November 17, 1995
Volume
83
Issue
4
Start / End Page
539 / 545
Location
United States
Related Subject Headings
- Yeasts
- Repetitive Sequences, Nucleic Acid
- Molecular Sequence Data
- Genotype
- Developmental Biology
- DNA-Directed DNA Polymerase
- DNA Repair
- Base Sequence
- 32 Biomedical and clinical sciences
- 31 Biological sciences