Transcription factors are required for the meiotic recombination hotspot at the HIS4 locus in Saccharomyces cerevisiae.
Publication
, Journal Article
White, MA; Dominska, M; Petes, TD
Published in: Proc Natl Acad Sci U S A
July 15, 1993
The full activity of a recombination initiation site located 5' of HIS4 requires the binding of the transcription factors RAP1, BAS1, and BAS2. Two RAP1 binding sites can substitute for the wild-type initiation site. A 51-bp region of telomeric DNA inserted upstream of either HIS4 or ARG4 very strongly stimulates recombination. We suggest that the ability of transcription factors to induce recombination is a consequence of an altered chromatin structure that favors the entry of proteins that initiate recombination, rather than an effect of these factors on transcription.
Duke Scholars
Published In
Proc Natl Acad Sci U S A
DOI
ISSN
0027-8424
Publication Date
July 15, 1993
Volume
90
Issue
14
Start / End Page
6621 / 6625
Location
United States
Related Subject Headings
- rap GTP-Binding Proteins
- Transcription, Genetic
- Transcription Factors
- Trans-Activators
- Telomere
- Sequence Deletion
- Saccharomyces cerevisiae Proteins
- Saccharomyces cerevisiae
- Recombination, Genetic
- Molecular Sequence Data
Citation
APA
Chicago
ICMJE
MLA
NLM
White, M. A., Dominska, M., & Petes, T. D. (1993). Transcription factors are required for the meiotic recombination hotspot at the HIS4 locus in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A, 90(14), 6621–6625. https://doi.org/10.1073/pnas.90.14.6621
White, M. A., M. Dominska, and T. D. Petes. “Transcription factors are required for the meiotic recombination hotspot at the HIS4 locus in Saccharomyces cerevisiae.” Proc Natl Acad Sci U S A 90, no. 14 (July 15, 1993): 6621–25. https://doi.org/10.1073/pnas.90.14.6621.
White MA, Dominska M, Petes TD. Transcription factors are required for the meiotic recombination hotspot at the HIS4 locus in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 1993 Jul 15;90(14):6621–5.
White, M. A., et al. “Transcription factors are required for the meiotic recombination hotspot at the HIS4 locus in Saccharomyces cerevisiae.” Proc Natl Acad Sci U S A, vol. 90, no. 14, July 1993, pp. 6621–25. Pubmed, doi:10.1073/pnas.90.14.6621.
White MA, Dominska M, Petes TD. Transcription factors are required for the meiotic recombination hotspot at the HIS4 locus in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 1993 Jul 15;90(14):6621–6625.
Published In
Proc Natl Acad Sci U S A
DOI
ISSN
0027-8424
Publication Date
July 15, 1993
Volume
90
Issue
14
Start / End Page
6621 / 6625
Location
United States
Related Subject Headings
- rap GTP-Binding Proteins
- Transcription, Genetic
- Transcription Factors
- Trans-Activators
- Telomere
- Sequence Deletion
- Saccharomyces cerevisiae Proteins
- Saccharomyces cerevisiae
- Recombination, Genetic
- Molecular Sequence Data