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Antinuclear antibodies in rheumatic disease: a proposal for a function-based classification.

Publication ,  Journal Article
Pisetsky, DS
Published in: Scand J Immunol
September 2012

Antinuclear antibodies (ANAs) are a diverse group of autoantibodies that bind macromolecular components of the cell nucleus. While some ANAs occur in normal individuals, others are expressed almost exclusively in patients with rheumatic disease and serve as markers for diagnosis and prognosis. Despite the clinical associations of ANAs, the relationship of these antibodies to specific disease manifestations is often unknown because the target antigens are intracellular molecules that are ubiquitously expressed. In systemic lupus erythematosus, the role of ANAs in disease manifestations is better understood, especially for antibodies to DNA and related nucleosomal antigens. These antibodies can promote nephritis by the formation of immune complexes that are deposited in the kidney. In addition, anti-DNA, along with antibodies to RNA-binding proteins such as anti-Sm, can induce non-specific immune abnormalities based on the induction of type interferon 1 by plasmacytoid dendritic cells. Despite ANA expression in rheumatic disease, studies in animal models of inflammation and tissue injury indicate that antibodies to certain nuclear molecules such as HMGB1 have protective effects. Together, these considerations suggest a function-based classification of ANAs based on their expression in normal and autoimmune individuals as well as their capacity to induce or attenuate immunological disturbances. This classification provides a framework to elucidate the serological features of rheumatic disease and the often uncertain relationship between ANA expression and disease manifestations.

Duke Scholars

Published In

Scand J Immunol

DOI

EISSN

1365-3083

Publication Date

September 2012

Volume

76

Issue

3

Start / End Page

223 / 228

Location

England

Related Subject Headings

  • Rheumatic Diseases
  • Lupus Erythematosus, Systemic
  • Immunology
  • Humans
  • Autoantigens
  • Antibodies, Antinuclear
  • Animals
  • 3204 Immunology
  • 1107 Immunology
 

Citation

APA
Chicago
ICMJE
MLA
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Pisetsky, D. S. (2012). Antinuclear antibodies in rheumatic disease: a proposal for a function-based classification. Scand J Immunol, 76(3), 223–228. https://doi.org/10.1111/j.1365-3083.2012.02728.x
Pisetsky, D. S. “Antinuclear antibodies in rheumatic disease: a proposal for a function-based classification.Scand J Immunol 76, no. 3 (September 2012): 223–28. https://doi.org/10.1111/j.1365-3083.2012.02728.x.
Pisetsky, D. S. “Antinuclear antibodies in rheumatic disease: a proposal for a function-based classification.Scand J Immunol, vol. 76, no. 3, Sept. 2012, pp. 223–28. Pubmed, doi:10.1111/j.1365-3083.2012.02728.x.
Journal cover image

Published In

Scand J Immunol

DOI

EISSN

1365-3083

Publication Date

September 2012

Volume

76

Issue

3

Start / End Page

223 / 228

Location

England

Related Subject Headings

  • Rheumatic Diseases
  • Lupus Erythematosus, Systemic
  • Immunology
  • Humans
  • Autoantigens
  • Antibodies, Antinuclear
  • Animals
  • 3204 Immunology
  • 1107 Immunology