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Neuropsychological correlates of magnetic resonance imaging-defined subcortical ischemic depression.

Publication ,  Journal Article
Potter, GG; McQuoid, DR; Steffens, DC; Welsh-Bohmer, KA; Krishnan, KRR
Published in: Int J Geriatr Psychiatry
March 2009

OBJECTIVE: The goal of the current study was to examine the neuropsychological profile of magnetic resonance imaging (MRI)-defined subcortical ischemic depression (SID). METHODS: Clinically depressed older adults with MRI-defined SID (n = 70) and depressed elders without SID (n = 75) were compared on neuropsychological performance, depression symptoms, and medical burden. RESULTS: Group comparisons revealed that the SID was associated with worse performance on all neuropsychological measures, but also with greater age, higher cardiac illness burden, and greater deficits in the depression symptoms of self-initiation and concentration. In multivariate regression models, auditory working memory and nonverbal memory remained worse among the SID group after controlling for contributions of age, cardiovascular risk, and depression symptoms. CONCLUSIONS: Although auditory working memory span and nonverbal memory appear to be specifically associated with the ischemic pathology that defines SID, the typical individual with SID is also likely to have a broader profile of neuropsychological deficits than those without SID because they are typically older and have specific depression symptoms that predispose them to compromised neurocognitive performance.

Duke Scholars

Published In

Int J Geriatr Psychiatry

DOI

EISSN

1099-1166

Publication Date

March 2009

Volume

24

Issue

3

Start / End Page

219 / 225

Location

England

Related Subject Headings

  • Risk Factors
  • Psychometrics
  • Neuropsychological Tests
  • Middle Aged
  • Male
  • Magnetic Resonance Angiography
  • Humans
  • Geriatrics
  • Geriatric Assessment
  • Female
 

Citation

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ICMJE
MLA
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Potter, G. G., McQuoid, D. R., Steffens, D. C., Welsh-Bohmer, K. A., & Krishnan, K. R. R. (2009). Neuropsychological correlates of magnetic resonance imaging-defined subcortical ischemic depression. Int J Geriatr Psychiatry, 24(3), 219–225. https://doi.org/10.1002/gps.2093
Potter, G. G., D. R. McQuoid, D. C. Steffens, K. A. Welsh-Bohmer, and K. R. R. Krishnan. “Neuropsychological correlates of magnetic resonance imaging-defined subcortical ischemic depression.Int J Geriatr Psychiatry 24, no. 3 (March 2009): 219–25. https://doi.org/10.1002/gps.2093.
Potter GG, McQuoid DR, Steffens DC, Welsh-Bohmer KA, Krishnan KRR. Neuropsychological correlates of magnetic resonance imaging-defined subcortical ischemic depression. Int J Geriatr Psychiatry. 2009 Mar;24(3):219–25.
Potter, G. G., et al. “Neuropsychological correlates of magnetic resonance imaging-defined subcortical ischemic depression.Int J Geriatr Psychiatry, vol. 24, no. 3, Mar. 2009, pp. 219–25. Pubmed, doi:10.1002/gps.2093.
Potter GG, McQuoid DR, Steffens DC, Welsh-Bohmer KA, Krishnan KRR. Neuropsychological correlates of magnetic resonance imaging-defined subcortical ischemic depression. Int J Geriatr Psychiatry. 2009 Mar;24(3):219–225.

Published In

Int J Geriatr Psychiatry

DOI

EISSN

1099-1166

Publication Date

March 2009

Volume

24

Issue

3

Start / End Page

219 / 225

Location

England

Related Subject Headings

  • Risk Factors
  • Psychometrics
  • Neuropsychological Tests
  • Middle Aged
  • Male
  • Magnetic Resonance Angiography
  • Humans
  • Geriatrics
  • Geriatric Assessment
  • Female