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Thymoma followed by paroxysmal nocturnal hemoglobinuria: a unique clinical association in the context of multiorgan autoimmunity with a potential role for CD8+ T lymphocytes.

Publication ,  Journal Article
Palmieri, G; Selleri, C; Montella, L; Bulgarelli, G; Vitiello, L; Merkabaoui, G; Ricci, P; Del Vecchio, L; Masci, A; Racioppi, L; Rotoli, B
Published in: Am J Hematol
October 2006

Seven years after a surgically resected thymoma, a female patient affected by myasthenia gravis and Good's syndrome presented with paroxysmal nocturnal hemoglobinuria (PNH). Co-culture experiments and spectratyping analyses indicated that CD8+ lymphocytes were involved in damaging hematopoietic precursors. While PNH clones have been identified in various hematological disorders, the sequential association of thymoma and PNH has been unreported so far.

Duke Scholars

Published In

Am J Hematol

DOI

ISSN

0361-8609

Publication Date

October 2006

Volume

81

Issue

10

Start / End Page

774 / 778

Location

United States

Related Subject Headings

  • Thymus Neoplasms
  • Thymoma
  • Reverse Transcriptase Polymerase Chain Reaction
  • Receptors, Antigen, T-Cell, alpha-beta
  • Neoplasm Recurrence, Local
  • Middle Aged
  • Immunology
  • Humans
  • Hemoglobinuria, Paroxysmal
  • Follow-Up Studies
 

Citation

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ICMJE
MLA
NLM
Palmieri, G., Selleri, C., Montella, L., Bulgarelli, G., Vitiello, L., Merkabaoui, G., … Rotoli, B. (2006). Thymoma followed by paroxysmal nocturnal hemoglobinuria: a unique clinical association in the context of multiorgan autoimmunity with a potential role for CD8+ T lymphocytes. Am J Hematol, 81(10), 774–778. https://doi.org/10.1002/ajh.20699
Palmieri, Giovannella, Carmine Selleri, Liliana Montella, Goffredo Bulgarelli, Laura Vitiello, Ghassan Merkabaoui, Patrizia Ricci, et al. “Thymoma followed by paroxysmal nocturnal hemoglobinuria: a unique clinical association in the context of multiorgan autoimmunity with a potential role for CD8+ T lymphocytes.Am J Hematol 81, no. 10 (October 2006): 774–78. https://doi.org/10.1002/ajh.20699.
Palmieri G, Selleri C, Montella L, Bulgarelli G, Vitiello L, Merkabaoui G, et al. Thymoma followed by paroxysmal nocturnal hemoglobinuria: a unique clinical association in the context of multiorgan autoimmunity with a potential role for CD8+ T lymphocytes. Am J Hematol. 2006 Oct;81(10):774–8.
Palmieri, Giovannella, et al. “Thymoma followed by paroxysmal nocturnal hemoglobinuria: a unique clinical association in the context of multiorgan autoimmunity with a potential role for CD8+ T lymphocytes.Am J Hematol, vol. 81, no. 10, Oct. 2006, pp. 774–78. Pubmed, doi:10.1002/ajh.20699.
Palmieri G, Selleri C, Montella L, Bulgarelli G, Vitiello L, Merkabaoui G, Ricci P, Del Vecchio L, Masci A, Racioppi L, Rotoli B. Thymoma followed by paroxysmal nocturnal hemoglobinuria: a unique clinical association in the context of multiorgan autoimmunity with a potential role for CD8+ T lymphocytes. Am J Hematol. 2006 Oct;81(10):774–778.
Journal cover image

Published In

Am J Hematol

DOI

ISSN

0361-8609

Publication Date

October 2006

Volume

81

Issue

10

Start / End Page

774 / 778

Location

United States

Related Subject Headings

  • Thymus Neoplasms
  • Thymoma
  • Reverse Transcriptase Polymerase Chain Reaction
  • Receptors, Antigen, T-Cell, alpha-beta
  • Neoplasm Recurrence, Local
  • Middle Aged
  • Immunology
  • Humans
  • Hemoglobinuria, Paroxysmal
  • Follow-Up Studies